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NCT03851406 · ClinicalTrials.gov registry record · NA
Woodsmoke Particulate + Hypertonic Saline
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 9
- Enrollment target
NCT03851406: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT03851406 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 9 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03851406, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
Study Summary
Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits. Inflammation is a key initial response to inhaled particulates. The investigator has developed a protocol using inhaled wood smoke particles (WSP) as a way to study PM-induced airway inflammation. Exposure to wood smoke particles causes symptoms, even in healthy people, such as eye irritation, cough, shortness of breath, and increased mucous production. The purpose of this research study is to see if a single treatment of inhaled hypertonic saline (HS) can diminish this PM-induced airway inflammation by rapidly clearing the WSP inhaled particles from airway surfaces. The exposure will be 500 ug/m³ of WSP for 2 hours, with intermittent exercise on a bicycle and rest. The wood is burned in a typical wood stove and piped into the chamber.
Primary Outcome
Change in sputum percent neutrophils from baseline to 4 hours post WSP exposure
Interventions
- OTHER No treatment
- DEVICE 5% Hypertonic Saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2019-08-01 |
| Est. Completion | 2024-09-12 |
| Phase | NA |
What the finished NCT03851406 record still lists
NCT03851406 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which No treatment is the first listed.
NCT03851406 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03851406 about?
NCT03851406 is a clinical study titled "Woodsmoke Particulate + Hypertonic Saline". Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits. Inflammation is a key initial response to inhaled particulates. The investigator has developed a protocol using inhal...
What is the current status of trial NCT03851406?
This trial is currently completed. It is a NA study. The enrollment target is 9 participants. The study started on 2019-08-01. Estimated completion is 2024-09-12.
What interventions are being tested in trial NCT03851406?
The interventions under investigation include: No treatment (OTHER), 5% Hypertonic Saline (DEVICE).
Who is sponsoring clinical trial NCT03851406?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03851406's enrollment target sits among peer trials
9 1975th of 2000 higher than 25 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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