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NCT03838146 · ClinicalTrials.gov registry record · NA
Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics
A NA study, sponsored by East Carolina University.
- Completed
- Registry status
- NA
- Development phase
- 167
- Enrollment target
NCT03838146 is a NA study that has completed, run by East Carolina University. The registered enrollment target is 167 participants.
The verdict
NCT03838146, a NA study, has completed, sponsored by East Carolina University.
- COMPLETED
- Registry status
- NA
- Development phase
- 167 participants
- Enrollment target
Study Summary
The American Heart Association suggests that heart disease prevention should target pregnancy and the first year of life; however, there is a fundamental gap in knowledge regarding the effects of prenatal exercise on the prevention of heart disease.\[1, 2\] Insulin resistance in skeletal muscle is believed to be a critical contributor to the metabolic syndrome which increases the risk for cardiovascular disease (CVD). Conversely, exercise improves insulin sensitivity and many other facets of skeletal muscle function and metabolism; however, it is unclear if this positive effect can be "imprinted" in the skeletal muscle of the fetus with maternal exercise and accordingly diminish CVD risk in offspring. Our previous studies found that exercise during pregnancy leads to improved heart measures and reduced adiposity.\[3-6\] These studies demonstrated the potential for maternal exercise to reduce risk for CVD, but the cellular mechanisms involved, however, are not clearly evident. The proposed project will fill this critical gap and assess the influence of maternal exercise intervention to "imprint" progenitor stem cells in the fetus (umbilical cord tissue) to develop into insulin sensitive skeletal muscle and also improve indices of infant morphometry and movement. Using a randomized design, 160 women will perform either exercise intervention (aerobic training, resistance training, or both) or usual care (controls). Infant cord tissue and blood will be sampled at birth while blood will be sampled at 1 month of age. Similarly, infant neuromotor and morphometric examinations will be performed at 1 month. and at 1-month of age via blood sample, neuromotor, and morphometric examinations. The rationale for the project is to elucidate the effects of maternal exercise on offspring health outcomes and determine specific metabolic targets predictive of offspring long-term disease risk. The investigators will test the central hypothesis that exercise during pregnancy alters skele
Interventions
- BEHAVIORAL Types of Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 167 participants |
| Start Date | 2018-09-01 |
| Est. Completion | 2023-01-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03838146
The ClinicalTrials.gov registry entry for NCT03838146 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 167 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is East Carolina University, which has 58 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Types of Exercise is the first listed.
NCT03838146 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03838146 about?
NCT03838146 is a clinical study titled "Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics". The American Heart Association suggests that heart disease prevention should target pregnancy and the first year of life; however, there is a fundamental gap in knowledge regarding the effects of prenatal exercise on the prevention of heart disease.\[1, 2\] Insulin resistance in skeletal muscle is b...
What is the current status of trial NCT03838146?
This trial is currently completed. It is a NA study. The enrollment target is 167 participants. The study started on 2018-09-01. Estimated completion is 2023-01-30.
What interventions are being tested in trial NCT03838146?
The interventions under investigation include: Types of Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT03838146?
This trial is sponsored by East Carolina University, which has 58 total clinical trials registered on ClinicalTrials.gov.
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