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CD4CAR for CD4+ Leukemia and Lymphoma
NCT03829540 · View on ClinicalTrials.gov ↗
Study Summary
This study is designed as a single arm open label Phase I, 3x3, multicenter study of CD4-directed chimeric antigen receptor engineered T-cells (CD4CAR) in patients with relapsed or refractory T-cell leukemia and lymphoma. Specifically, the study will evaluate the safety and feasibility of CD4CAR T-cells. Funding Source - FDA OOPD
Conditions Studied
Interventions
- BIOLOGICAL CD4CAR
Study Locations (6)
Indiana
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis
- Riley Hospital for Children — Indianapolis
New York
- Albert Einstein Health Network — New York
- Stony Brook Cancer Center — Stony Brook
Florida
- University of Miami Sylvester Comprehensive Cancer Center — Miami
Texas
- The University of Texas MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2020-07-09 |
| Est. Completion | 2041-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03829540
The ClinicalTrials.gov registry entry for NCT03829540 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Huda Salman, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with T-cell Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which CD4CAR is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03829540 reports 6 study locations spanning 4 distinct geographic areas — top geographies include Indiana, New York, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03829540 about?
NCT03829540 is a clinical study titled "CD4CAR for CD4+ Leukemia and Lymphoma". This study is designed as a single arm open label Phase I, 3x3, multicenter study of CD4-directed chimeric antigen receptor engineered T-cells (CD4CAR) in patients with relapsed or refractory T-cell leukemia and lymphoma. Specifically, the study will evaluate the safety and feasibility of CD4CAR T-c...
What is the current status of trial NCT03829540?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2020-07-09. Estimated completion is 2041-12.
What conditions does trial NCT03829540 study?
This clinical trial studies the following conditions: T-cell Lymphoma, T-cell Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03829540?
The interventions under investigation include: CD4CAR (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03829540?
This trial is sponsored by Huda Salman, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03829540 being conducted?
This trial has 6 study locations across Florida, Indiana, New York, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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