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A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
NCT03952078 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1/1b, open-label, first in human study of CPI-818, an oral interleukin-2-inducible tyrosine kinase (ITK) inhibitor for the treatment of relapsed/refractory (R/R) T-cell lymphoma.. This trial will study the safety, tolerability, and anti-tumor activity of CPI-818 as a single drug.
Conditions Studied
Interventions
- DRUG CPI-818
Study Locations (20)
Gyeonggido
- Seoul National University Hospital — Seoul
- Asan Medical Center — Seoul
- Samsung Medical Center — Seoul
- Seoul St. Mary's Hospital — Seoul
Beijing Municipality
- Beijing Friendship Hospital — Beijing
- Beijing Boren Hospital — Beijing
- Beijing Cancer Hospital — Beijing
New South Wales
- Concord Repatriation General Hospital — Concord
- Liverpool Hospital — Liverpool
California
- Stanford University — Palo Alto
Michigan
- University of Michigan — Ann Arbor
Missouri
- Washington University — St Louis
New Jersey
- Hackensack University Medical Center — Hackensack
Ohio
- Ohio State University — Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 151 participants |
| Start Date | 2019-05-03 |
| Est. Completion | 2026-04-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03952078
The ClinicalTrials.gov registry entry for NCT03952078 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 151 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Corvus Pharmaceuticals, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with T-cell Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which CPI-818 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03952078 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Gyeonggido, Beijing Municipality, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03952078 about?
NCT03952078 is a clinical study titled "A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma". This is a Phase 1/1b, open-label, first in human study of CPI-818, an oral interleukin-2-inducible tyrosine kinase (ITK) inhibitor for the treatment of relapsed/refractory (R/R) T-cell lymphoma.. This trial will study the safety, tolerability, and anti-tumor activity of CPI-818 as a single drug.
What is the current status of trial NCT03952078?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 151 participants. The study started on 2019-05-03. Estimated completion is 2026-04-30.
What conditions does trial NCT03952078 study?
This clinical trial studies the following conditions: T-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03952078?
The interventions under investigation include: CPI-818 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03952078?
This trial is sponsored by Corvus Pharmaceuticals, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03952078 being conducted?
This trial has 20 study locations across California, Michigan, Missouri, New Jersey, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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