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NCT03828604 · ClinicalTrials.gov registry record · NA
Stress-Induced Inflammation and Reward Processing
A NA study of Stress, Psychological, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- NA
- Development phase
- 57
- Enrollment target
- 1
- Study location
NCT03828604: Completed NA study of Stress, Psychological, sponsored by University of California, Los Angeles.
NCT03828604 is a NA study of Stress, Psychological that has completed, run by University of California, Los Angeles. The registered enrollment target is 57 participants, below the 170-participant average among 43 other Stress, Psychological trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03828604, a NA study of Stress, Psychological, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- NA
- Development phase
- 57 participants
- Enrollment target
- 1
- Study location
Study Summary
Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a key psychobiological pathway to anhedonic behavior; however, this pathway has not been demonstrated in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. The current placebo controlled study used a standardized laboratory stressor task to elicit an inflammatory response in a sample of a healthy young women and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.
Primary Outcome
Change in the magnitude of response bias from pre to post Trier Social Stress Task (TSST) or Placebo-TSST (P-TSST).
Conditions Studied
Interventions
- BEHAVIORAL Stress; Trier Social Stress Task
- BEHAVIORAL Placebo Trier Social Stress Task
Study Locations (1)
California
- Clinical and Translational Research Center, University of California, Los Angeles - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2017-05-12 |
| Est. Completion | 2018-05-09 |
| Phase | NA |
What the finished NCT03828604 record still lists
NCT03828604 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 57 participants, a relatively small participant target, below the 170-participant average among 43 other Stress, Psychological trials with a reported enrollment target (66% lower).
The record links to 1 condition, with Stress, Psychological appearing as the primary indexed condition, and to 2 interventions - of which Stress; Trier Social Stress Task is the first listed.
NCT03828604 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT03828604 about?
NCT03828604 is a clinical study titled "Stress-Induced Inflammation and Reward Processing". Anhedonia, or loss of interest or pleasure, is a key feature of depression and transdiagnostic construct in psychopathology. Both theory and compelling evidence from preclinical models implicates stress-induced inflammation as a key psychobiological pathway to anhedonic behavior; however, this pathw...
What is the current status of trial NCT03828604?
This trial is currently completed. It is a NA study. The enrollment target is 57 participants. The study started on 2017-05-12. Estimated completion is 2018-05-09.
What conditions does trial NCT03828604 study?
This clinical trial studies the following conditions: Stress, Psychological.
What interventions are being tested in trial NCT03828604?
The interventions under investigation include: Stress; Trier Social Stress Task (BEHAVIORAL), Placebo Trier Social Stress Task (BEHAVIORAL).
Who is sponsoring clinical trial NCT03828604?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03828604 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stress, Psychological
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03828604's enrollment target sits among peer trials
57 29th of 43 higher than 15 of 43 other Stress, Psychological trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stress, Psychological trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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