Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03826147 · ClinicalTrials.gov registry record · Phase 4
Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease
A Phase 4 study, sponsored by University of Colorado, Boulder.
- Active
- Registry status
- Phase 4
- Development phase
- 92
- Enrollment target
NCT03826147: Active Phase 4 study, sponsored by University of Colorado, Boulder.
NCT03826147 is a Phase 4 study that is active but no longer recruiting, run by University of Colorado, Boulder. The registered enrollment target is 92 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03826147, a Phase 4 study, is active but no longer recruiting, sponsored by University of Colorado, Boulder.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 92 participants
- Enrollment target
Study Summary
Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases NO in the body, i.e., nitrate-rich beetroot juice, improves vascular, motor and cognitive function in patients with CKD; this study will also provide insight into the biological reasons (mechanisms) by which supplementation with nitrate-rich beetroot juice improves vascular function in these patients. Overall, this research will provide scientific evidence supporting the use of nitrate-rich beetroot juice for preserving physiological function and preventing co-morbid clinical conditions and disability in CKD.
Primary Outcome
as measured by brachial artery flow-mediated dilation
Interventions
- DIETARY_SUPPLEMENT Nitrate-rich beetroot juice
- DIETARY_SUPPLEMENT Nitrate-depleted beetroot juice
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 92 participants |
| Start Date | 2019-05-01 |
| Est. Completion | 2026-08 |
| Phase | Phase 4 |
What the registry record for NCT03826147 still lists
NCT03826147 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 92 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 2 interventions - of which Nitrate-rich beetroot juice is the first listed.
NCT03826147 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03826147 about?
NCT03826147 is a clinical study titled "Nitrite-boosting Therapy for Improving Physiological Function in Patients With Chronic Kidney Disease". Nitric oxide (NO) is an essential molecule in the body that is decreased in patients with chronic kidney disease (CKD), leading to reductions in vascular, movement ("motor") and cognitive functions. This study will determine if daily oral supplementation (3 months) with a supplement that increases N...
What is the current status of trial NCT03826147?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 92 participants. The study started on 2019-05-01. Estimated completion is 2026-08.
What interventions are being tested in trial NCT03826147?
The interventions under investigation include: Nitrate-rich beetroot juice (DIETARY_SUPPLEMENT), Nitrate-depleted beetroot juice (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03826147?
This trial is sponsored by University of Colorado, Boulder, which has 69 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03826147's enrollment target sits among peer trials
92 876th of 2000 higher than 1,117 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03184545 · 92 participants · Phase 3
Comparing the Outcome of Electrical Stimulation and Physical Therapy in Patellofemoral Pain Syndrome
- NCT04172532 · 92 participants · Phase 1
Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer
- NCT04508088 · 92 participants
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
- NCT04840602 · 92 participants · Phase 2
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI