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NCT03822910 · ClinicalTrials.gov registry record
Hippocampal Memory Circuits in Delusions
A clinical trial, sponsored by NYU Langone Health.
- Completed
- Registry status
- 212
- Enrollment target
NCT03822910: Completed study, sponsored by NYU Langone Health.
NCT03822910 is a clinical trial that has completed, run by NYU Langone Health. The registered enrollment target is 212 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03822910 has completed, sponsored by NYU Langone Health.
- COMPLETED
- Registry status
- 212 participants
- Enrollment target
Study Summary
This study will investigate dentate gyrus (DG) and hippocampal CA3 sub field function, using the pattern separation paradigm, as reflected by the difference in brain activation in response to same-as-previously- seen (OLD) vs. similar-to-previously-seen (SIM) objects in first episode psychosis (FEP) subjects before and after anti psychotic treatment and in matched healthy controls (HC). The current study uses three novel high-resolution task-based and post-encoding resting fMRI measures to probe hippocampal circuitry in delusions. It will also study CA1 function, using a sequential associative mismatch paradigm, as reflected by activation of CA1 in response to mismatching information compared to memory of that stimulus in FEP subjects before and after antipsychotic treatment and in matched HC. Finally, this study will evaluate plasticity of hippocampal intrinsic functional connectivity (IFC) in response to memory consolidation, using an encoding-plasticity paradigm, in FEP subjects before and after anti psychotic treatment and in matched HC. For each of the three imaging projects, a total of 50 FEP subjects and 50 matched healthy controls (HC) will be studied; hence, 300 subjects will be studied over 5 years. Within each paradigm, medication-naive FEP subjects will be studied at baseline and 8 weeks after starting anti psychotic medication. HC participants will be studied at baseline and 8 weeks later but will not receive any treatment.
Interventions
- DIAGNOSTIC_TEST Pattern Separation Paradigm
- DIAGNOSTIC_TEST Sequential Associative Mismatch Paradigm
- DIAGNOSTIC_TEST Encoding Plasticity Paradigm
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 212 participants |
| Start Date | 2019-07-13 |
| Est. Completion | 2023-08-12 |
What the finished NCT03822910 record still lists
NCT03822910 is an observational study that tracks outcomes without assigning an intervention. The registered 212 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 3 interventions - of which Pattern Separation Paradigm is the first listed.
NCT03822910 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03822910 about?
NCT03822910 is a clinical study titled "Hippocampal Memory Circuits in Delusions". This study will investigate dentate gyrus (DG) and hippocampal CA3 sub field function, using the pattern separation paradigm, as reflected by the difference in brain activation in response to same-as-previously- seen (OLD) vs. similar-to-previously-seen (SIM) objects in first episode psychosis (FEP)...
What is the current status of trial NCT03822910?
This trial is currently completed. The enrollment target is 212 participants. The study started on 2019-07-13. Estimated completion is 2023-08-12.
What interventions are being tested in trial NCT03822910?
The interventions under investigation include: Pattern Separation Paradigm (DIAGNOSTIC_TEST), Sequential Associative Mismatch Paradigm (DIAGNOSTIC_TEST), Encoding Plasticity Paradigm (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03822910?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
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