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NCT03794544 · ClinicalTrials.gov registry record · Phase 2
Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer
A Phase 2 study, sponsored by MedImmune.
- Completed
- Registry status
- Phase 2
- Development phase
- 84
- Enrollment target
NCT03794544: Completed Phase 2 study, sponsored by MedImmune.
NCT03794544 is a Phase 2 study that has completed, run by MedImmune. The registered enrollment target is 84 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (37% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03794544, a Phase 2 study, has completed, sponsored by MedImmune.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 84 participants
- Enrollment target
Study Summary
Study D9108C00002 (NeoCOAST) is a platform study assessing the effectiveness and safety of neoadjuvant durvalumab alone or in combination with novel agents in participants with resectable, early-stage (Stage I \[\>2cm\] to IIIA) non-small cell lung cancer (NSCLC).
Primary Outcome
Major pathological response rate is defined as percentage of participants with \<=10% residual viable tumor cells in the resected specimen.
Interventions
- DRUG Durvalumab
- COMBINATION_PRODUCT Oleclumab
- COMBINATION_PRODUCT Monalizumab
- COMBINATION_PRODUCT Danvatirsen
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2019-03-08 |
| Est. Completion | 2021-01-13 |
| Phase | Phase 2 |
What the finished NCT03794544 record still lists
NCT03794544 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 84 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (37% lower).
The record links to 0 conditions, and to 4 interventions - of which Durvalumab is the first listed.
NCT03794544 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03794544 about?
NCT03794544 is a clinical study titled "Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer". Study D9108C00002 (NeoCOAST) is a platform study assessing the effectiveness and safety of neoadjuvant durvalumab alone or in combination with novel agents in participants with resectable, early-stage (Stage I \[\>2cm\] to IIIA) non-small cell lung cancer (NSCLC).
What is the current status of trial NCT03794544?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 84 participants. The study started on 2019-03-08. Estimated completion is 2021-01-13.
What interventions are being tested in trial NCT03794544?
The interventions under investigation include: Durvalumab (DRUG), Oleclumab (COMBINATION_PRODUCT), Monalizumab (COMBINATION_PRODUCT), Danvatirsen (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT03794544?
This trial is sponsored by MedImmune, which has 210 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03794544's enrollment target sits among peer trials
84 822nd of 2000 higher than 1,173 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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