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NCT03787732 · ClinicalTrials.gov registry record · Phase 4
Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
A Phase 4 study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 1,067
- Enrollment target
NCT03787732 is a Phase 4 study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 1,067 participants.
The verdict
NCT03787732, a Phase 4 study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 1,067 participants
- Enrollment target
Study Summary
Complications are common during tracheal intubation of critically ill patients. Nearly one in five patients undergoing intubation in the intensive care unit experiences cardiovascular collapse, defined as severe hypotension, vasopressor administration, cardiac arrest or death. Cardiovascular collapse during intubation is associated with increased resource utilization and decreased survival. Administration of 500 mL of intravenous crystalloid solution beginning prior to induction may prevent cardiovascular collapse. The only prior trial examining fluid bolus administration during intubation found no effect on cardiovascular collapse or clinical outcomes overall, but a hypothesis-generating subgroup analysis suggested potential benefit to fluid bolus administration among patients receiving positive pressure ventilation between induction and laryngoscopy. Therefore, we propose a randomized trial comparing fluid bolus administration versus none with regard to cardiovascular collapse among critically adults undergoing intubation with positive pressure ventilation between induction and laryngoscopy.
Interventions
- DRUG Fluid Bolus
- OTHER No Fluid Bolus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,067 participants |
| Start Date | 2019-02-01 |
| Est. Completion | 2021-06-21 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03787732
The ClinicalTrials.gov registry entry for NCT03787732 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 1,067 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Fluid Bolus is the first listed.
NCT03787732 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03787732 about?
NCT03787732 is a clinical study titled "Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation". Complications are common during tracheal intubation of critically ill patients. Nearly one in five patients undergoing intubation in the intensive care unit experiences cardiovascular collapse, defined as severe hypotension, vasopressor administration, cardiac arrest or death. Cardiovascular collaps...
What is the current status of trial NCT03787732?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 1,067 participants. The study started on 2019-02-01. Estimated completion is 2021-06-21.
What interventions are being tested in trial NCT03787732?
The interventions under investigation include: Fluid Bolus (DRUG), No Fluid Bolus (OTHER).
Who is sponsoring clinical trial NCT03787732?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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