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NCT03785470 · ClinicalTrials.gov registry record · NA
Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle
A NA study, sponsored by University of Missouri-Columbia.
- Completed
- Registry status
- NA
- Development phase
- 52
- Enrollment target
NCT03785470: Completed NA study, sponsored by University of Missouri-Columbia.
NCT03785470 is a NA study that has completed, run by University of Missouri-Columbia. The registered enrollment target is 52 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03785470, a NA study, has completed, sponsored by University of Missouri-Columbia.
- COMPLETED
- Registry status
- NA
- Development phase
- 52 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if short-term adoption of a Westernized lifestyle characterized by physical inactivity and increased consumption of fructose will result in metabolic and vascular dysfunction. Healthy individuals aged 18-45 years old will undergo an acute period of physical inactivity (10 days) coupled with increased fructose consumption. Augmented fructose consumption will be achieved via commercially available soda beverages which are high in fructose. Vascular and metabolic function measures will be performed before and after the 10-day intervention.
Primary Outcome
Subjects will be instrumented with EKG for contrast-enhanced ultrasound (CEU) measurements. We will perform a hyperinsulinemic euglycemic clamp to evaluate microvascular perfusion of skeletal muscle via CEU. Insulin will be infused at a constant rate to mimic postprandial insulin concentrations and glucose maintained at fasting values via a variable 20% dextrose infusion. At baseline and in the steady state phase of the insulin clamp, we will assess microvascular perfusion in the vastus laterali
Interventions
- OTHER Fructose and physical inactivity
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2018-11-30 |
| Est. Completion | 2022-08-16 |
| Phase | NA |
What the finished NCT03785470 record still lists
NCT03785470 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Fructose and physical inactivity is the first listed.
NCT03785470 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03785470 about?
NCT03785470 is a clinical study titled "Vascular and Metabolic Consequences of Adopting a Westernized Lifestyle". The purpose of this study is to determine if short-term adoption of a Westernized lifestyle characterized by physical inactivity and increased consumption of fructose will result in metabolic and vascular dysfunction. Healthy individuals aged 18-45 years old will undergo an acute period of physical ...
What is the current status of trial NCT03785470?
This trial is currently completed. It is a NA study. The enrollment target is 52 participants. The study started on 2018-11-30. Estimated completion is 2022-08-16.
What interventions are being tested in trial NCT03785470?
The interventions under investigation include: Fructose and physical inactivity (OTHER).
Who is sponsoring clinical trial NCT03785470?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03785470's enrollment target sits among peer trials
52 1272nd of 2000 higher than 722 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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