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NCT03775382 · ClinicalTrials.gov registry record · NA
Mechanisms of Impaired Brain Blood Flow With Aging
A NA study, sponsored by University of Delaware.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT03775382: Completed NA study, sponsored by University of Delaware.
NCT03775382 is a NA study that has completed, run by University of Delaware. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03775382, a NA study, has completed, sponsored by University of Delaware.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into the factors linking advancing age to increased risk for AD and thereby lead to new therapeutic targets for preventing or slowing AD progression. Cardiovascular changes, including impaired cerebrovascular function, occur with aging and may increase risk for AD; however, the mechanisms by which cerebrovascular function becomes impaired in older adults are incompletely understood. The overall goal of this project is to examine potential mechanisms of age-related declines in cerebrovascular function in humans. The investigators hypothesize that brain macro-vascular endothelial dysfunction, secondary to oxidative stress, plays an important role in mediating age-related changes in brain blood flow and cerebrovascular reactivity. The results of this pilot study have the potential to identify novel targets of cerebrovascular aging and will help guide the design of future clinical trials aimed at improving cerebral blood flow in older adults.
Primary Outcome
Cerebrovascular reactivity to hypercapnia
Interventions
- OTHER Normal Saline
- OTHER Ascorbic Acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2017-10-30 |
| Est. Completion | 2022-06-01 |
| Phase | NA |
What the finished NCT03775382 record still lists
NCT03775382 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Normal Saline is the first listed.
NCT03775382 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03775382 about?
NCT03775382 is a clinical study titled "Mechanisms of Impaired Brain Blood Flow With Aging". Aging is the primary risk factor for Alzheimer's disease (AD), which is a rapidly growing public health concern. Understanding the mechanisms of normal brain aging may provide insight into the factors linking advancing age to increased risk for AD and thereby lead to new therapeutic targets for prev...
What is the current status of trial NCT03775382?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2017-10-30. Estimated completion is 2022-06-01.
What interventions are being tested in trial NCT03775382?
The interventions under investigation include: Normal Saline (OTHER), Ascorbic Acid (OTHER).
Who is sponsoring clinical trial NCT03775382?
This trial is sponsored by University of Delaware, which has 106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03775382's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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