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NCT03726671 · ClinicalTrials.gov registry record · NA
Choline Nutritional Status: Development of a Biomarker Panel
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 101
- Enrollment target
NCT03726671: Completed NA study, sponsored by University of North Carolina, Chapel Hill.
NCT03726671 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 101 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03726671, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 101 participants
- Enrollment target
Study Summary
People who eat diets low in choline should deplete their choline (Cho) stores, and measurements of Cho pool size using isotope dilution should reflect this depletion. Investigators will identify a biomarker panel that correlates well with measured Cho pool size across the range of different degrees of depletion.The investigators propose that, as body stores of Cho diminish, cells and organs will reach the point when metabolism/function in the cell is altered, and that this will result in a progression of changes in biomarkers that reflect Cho status.
Primary Outcome
The liver choline pool determined by the dilution of the deuterated choline metabolites formed in liver and released to plasma as measured by isotopic enrichment ratio (IER). The IER for a given metabolite is defined as the concentration of a deuterated metabolite divided by the sum of deuterated and non-deuterated metabolite.
Interventions
- OTHER 25% Cho diet
- OTHER 50% Cho diet
- OTHER 100% Cho diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 101 participants |
| Start Date | 2018-11-01 |
| Est. Completion | 2021-10-20 |
| Phase | NA |
What the finished NCT03726671 record still lists
NCT03726671 is an interventional study that assigns participants to a tested intervention. The registered 101 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 3 interventions - of which 25% Cho diet is the first listed.
NCT03726671 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03726671 about?
NCT03726671 is a clinical study titled "Choline Nutritional Status: Development of a Biomarker Panel". People who eat diets low in choline should deplete their choline (Cho) stores, and measurements of Cho pool size using isotope dilution should reflect this depletion. Investigators will identify a biomarker panel that correlates well with measured Cho pool size across the range of different degrees ...
What is the current status of trial NCT03726671?
This trial is currently completed. It is a NA study. The enrollment target is 101 participants. The study started on 2018-11-01. Estimated completion is 2021-10-20.
What interventions are being tested in trial NCT03726671?
The interventions under investigation include: 25% Cho diet (OTHER), 50% Cho diet (OTHER), 100% Cho diet (OTHER).
Who is sponsoring clinical trial NCT03726671?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03726671's enrollment target sits among peer trials
101 840th of 2000 higher than 1,161 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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