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NCT03718520 · ClinicalTrials.gov registry record
The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
A clinical trial, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 168
- Enrollment target
NCT03718520: Completed study, sponsored by University of Colorado, Denver.
NCT03718520 is a clinical trial that has completed, run by University of Colorado, Denver. The registered enrollment target is 168 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03718520 has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 168 participants
- Enrollment target
Study Summary
Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid receptors, disrupting the endogenous cannabinoid signaling system during a critical period of development of cortical circuitry structure and function. The density of cannabinoid receptors in the developing brain is high, especially in the limbic areas and prefrontal lobes. Research in animal models suggests synaptic plasticity in the prefrontal lobes as well the amygdala and hippocampus are impacted by the prenatal cannabis exposure; regions associated with both cognitive and emotional control, thus influencing long-term deficiencies in attention and impulsivity. This pilot study will collect preliminary data on the structural impact of in utero cannabis exposure on region-specific morphology and structural connectivity of white matter tracts that connect to the prefrontal lobes and the limbic regions shortly after birth, before confounding by the postnatal environment becomes a major influence.
Primary Outcome
region specific volume (mm\^2)
Interventions
- OTHER no intervention, this is a purely observational study
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2018-11-07 |
| Est. Completion | 2020-03-31 |
What the finished NCT03718520 record still lists
NCT03718520 is an observational study that tracks outcomes without assigning an intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which no intervention, this is a purely observational study is the first listed.
NCT03718520 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03718520 about?
NCT03718520 is a clinical study titled "The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity". Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid receptors, disrupting the endogenous cannabinoid signaling system during a cri...
What is the current status of trial NCT03718520?
This trial is currently completed. The enrollment target is 168 participants. The study started on 2018-11-07. Estimated completion is 2020-03-31.
What interventions are being tested in trial NCT03718520?
The interventions under investigation include: no intervention, this is a purely observational study (OTHER).
Who is sponsoring clinical trial NCT03718520?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
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