Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03718520 · ClinicalTrials.gov registry record
The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity
A clinical trial, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 168
- Enrollment target
NCT03718520 is a clinical trial that has completed, run by University of Colorado, Denver. The registered enrollment target is 168 participants.
The verdict
NCT03718520 has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 168 participants
- Enrollment target
Study Summary
Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid receptors, disrupting the endogenous cannabinoid signaling system during a critical period of development of cortical circuitry structure and function. The density of cannabinoid receptors in the developing brain is high, especially in the limbic areas and prefrontal lobes. Research in animal models suggests synaptic plasticity in the prefrontal lobes as well the amygdala and hippocampus are impacted by the prenatal cannabis exposure; regions associated with both cognitive and emotional control, thus influencing long-term deficiencies in attention and impulsivity. This pilot study will collect preliminary data on the structural impact of in utero cannabis exposure on region-specific morphology and structural connectivity of white matter tracts that connect to the prefrontal lobes and the limbic regions shortly after birth, before confounding by the postnatal environment becomes a major influence.
Interventions
- OTHER no intervention, this is a purely observational study
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2018-11-07 |
| Est. Completion | 2020-03-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03718520
The ClinicalTrials.gov registry entry for NCT03718520 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 168 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Colorado, Denver, which has 1,283 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which no intervention, this is a purely observational study is the first listed.
NCT03718520 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03718520 about?
NCT03718520 is a clinical study titled "The Influence of in Utero Cannabis Exposure on Neonatal Brain Morphology and Structural Connectivity". Cannabis is the most commonly used drug by women during pregnancy with an estimated prevalence of use in Colorado of 5.7%. THC and its metabolites freely cross the placenta and blood-brain barrier to bind with cannabinoid receptors, disrupting the endogenous cannabinoid signaling system during a cri...
What is the current status of trial NCT03718520?
This trial is currently completed. The enrollment target is 168 participants. The study started on 2018-11-07. Estimated completion is 2020-03-31.
What interventions are being tested in trial NCT03718520?
The interventions under investigation include: no intervention, this is a purely observational study (OTHER).
Who is sponsoring clinical trial NCT03718520?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.