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NCT03704688 · ClinicalTrials.gov registry record · Phase 1
Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer
A Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT03704688: Completed Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
NCT03704688 is a Phase 1 study that has completed, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 12 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03704688, a Phase 1 study, has completed, sponsored by Memorial Sloan Kettering Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate the safety of the combination of ponatinib and trametinib as well as the most appropriate dosages of the combination.
Primary Outcome
In the Phase I portion of the study, a standard 3+3 design will be used to find the maximum tolerated dose.
Interventions
- DRUG Trametinib 0.5 mg
- DRUG Trametinib 1 MG
- DRUG Trametinib 1.5 MG
- DRUG Trametinib 2 mg
- DRUG Ponatinib 15 MG
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2018-10-09 |
| Est. Completion | 2022-02-04 |
| Phase | Phase 1 |
What the finished NCT03704688 record still lists
NCT03704688 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower).
The record links to 0 conditions, and to 5 interventions - of which Trametinib 0.5 mg is the first listed.
NCT03704688 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03704688 about?
NCT03704688 is a clinical study titled "Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer". The purpose of this study is to evaluate the safety of the combination of ponatinib and trametinib as well as the most appropriate dosages of the combination.
What is the current status of trial NCT03704688?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2018-10-09. Estimated completion is 2022-02-04.
What interventions are being tested in trial NCT03704688?
The interventions under investigation include: Trametinib 0.5 mg (DRUG), Trametinib 1 MG (DRUG), Trametinib 1.5 MG (DRUG), Trametinib 2 mg (DRUG), Ponatinib 15 MG (DRUG).
Who is sponsoring clinical trial NCT03704688?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03704688's enrollment target sits among peer trials
12 1852nd of 2000 higher than 90 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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