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NCT03657212 · ClinicalTrials.gov registry record · Phase 4
Enhancing Memory Consolidation in Older Adults
A Phase 4 study, sponsored by University of California, Irvine.
- Terminated
- Registry status
- Phase 4
- Development phase
- 10
- Enrollment target
NCT03657212: Clinical Trial Phase 4 study, sponsored by University of California, Irvine.
NCT03657212 is a Phase 4 study that was terminated before completion, run by University of California, Irvine. The registered enrollment target is 10 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03657212, a Phase 4 study, was terminated before completion, sponsored by University of California, Irvine.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 10 participants
- Enrollment target
Study Summary
The purpose of this research study is to understand the neural mechanisms underlying long-term memory formation in older adults. Both sleep and memory decrease with age. The investigators are interested in discovering whether these two biological changes are related. This study is specifically focused on understanding what are the critical components of sleep that facilitate memory formation and are they impaired in older adults. The investigators will be using the hypnotic zolpidem, a sleep drug that has been shown to increase a specific aspect of sleep that have been shown to correlate with memory improvement in young adults. The Food and Drug Administration (FDA) have approved zolpidem for use in certain sleep disorders, specifically in the treatment of sleeplessness (i.e., insomnia). In the current study, the investigators will examine whether zolpidem (5mg), compared with placebo, increases memory-related sleep events in older adults and test the impact of these drug-related sleep changes on post-sleep memory recall. This is a research study because the investigators are using pharmacological interventions to investigate our hypotheses about memory consolidation. The investigators are not studying the efficacy of zolpidem to treat conditions for which the FDA has already approved it.
Primary Outcome
The investigators will assess change in performance on a memory task that will be tested before and after the drug intervention. Subjects will study word lists before the intervention and their recall will be tested after the intervention.
Interventions
- DRUG Zolpidem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2018-10-01 |
| Est. Completion | 2019-01-01 |
| Phase | Phase 4 |
Why NCT03657212 stopped before completion
NCT03657212 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Zolpidem is the first listed.
NCT03657212 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03657212 about?
NCT03657212 is a clinical study titled "Enhancing Memory Consolidation in Older Adults". The purpose of this research study is to understand the neural mechanisms underlying long-term memory formation in older adults. Both sleep and memory decrease with age. The investigators are interested in discovering whether these two biological changes are related. This study is specifically focus...
What is the current status of trial NCT03657212?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 10 participants. The study started on 2018-10-01. Estimated completion is 2019-01-01.
What interventions are being tested in trial NCT03657212?
The interventions under investigation include: Zolpidem (DRUG).
Who is sponsoring clinical trial NCT03657212?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03657212's enrollment target sits among peer trials
10 1940th of 2000 higher than 33 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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