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NCT03648762 · ClinicalTrials.gov registry record · NA
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit
A NA study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 65
- Enrollment target
NCT03648762: Completed NA study, sponsored by VA Office of Research and Development.
NCT03648762 is a NA study that has completed, run by VA Office of Research and Development. The registered enrollment target is 65 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03648762, a NA study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 65 participants
- Enrollment target
Study Summary
The purpose of this research study is to better understand how exercise training in older adults (≥65 years) with heart failure (HF) affects skeletal muscle both intrinsically and in respect to its impact on functional capacity. While many conceptualize HF as a pathophysiology that exclusively affects the heart, skeletal muscle atrophy and weakening are also elemental to the disease. While reduced exercise capacity is typically associated with HF, this may be related more to disease effects in skeletal muscle than the heart. This is a clinical study that focuses on exercise training which compares functional endpoints before and after training. Patients are randomized to one of three exercise training interventions (aerobic vs. aerobic and strength vs. inspiratory muscle training) for 12 weeks and are assessed pre- and post-training to determine if any differences occur in their skeletal muscle and functional capacity. Skeletal muscle biopsies before and after the exercise training intervention in order to study changes in skeletal muscle histology and biology. Functional endpoints in this study include ventilatory gas indices from cardiopulmonary exercise testing, lower body strength testing, grip strength, sit-to-stand, six-minute-walk distance, gait speed, inspiratory muscle strength, and quality of life and physical activity-oriented questionnaires, including the Kansas City Cardiomyopathy Questionnaire, Duke Activity Status Index, and CHAMPS Physical Activity Questionnaire for Older Adults. Body composition is measured with Dual Energy X-ray (DXA) scanning. Skeletal muscle biopsies are completed in the vastus lateralis of the non-dominant leg to assess histology and biologic endpoints.
Primary Outcome
a cardiopulmonary exercise test will be performed to determined peak VO2 in ML/KG/Min
Interventions
- BEHAVIORAL Aerobic Exercise Intervention
- BEHAVIORAL Combined Aerobic and Strength Exercise Intervention
- BEHAVIORAL Inspiratory Muscle Training Exercise Intervention
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2017-05-08 |
| Est. Completion | 2019-09-30 |
| Phase | NA |
What the finished NCT03648762 record still lists
NCT03648762 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 3 interventions - of which Aerobic Exercise Intervention is the first listed.
NCT03648762 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03648762 about?
NCT03648762 is a clinical study titled "Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit". The purpose of this research study is to better understand how exercise training in older adults (≥65 years) with heart failure (HF) affects skeletal muscle both intrinsically and in respect to its impact on functional capacity. While many conceptualize HF as a pathophysiology that exclusively affec...
What is the current status of trial NCT03648762?
This trial is currently completed. It is a NA study. The enrollment target is 65 participants. The study started on 2017-05-08. Estimated completion is 2019-09-30.
What interventions are being tested in trial NCT03648762?
The interventions under investigation include: Aerobic Exercise Intervention (BEHAVIORAL), Combined Aerobic and Strength Exercise Intervention (BEHAVIORAL), Inspiratory Muscle Training Exercise Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT03648762?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03648762's enrollment target sits among peer trials
65 1144th of 2000 higher than 854 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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