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NCT03642769 · ClinicalTrials.gov registry record · NA
Lactated Ringer's Versus Normal Saline for Acute Pancreatitis
A NA study, sponsored by University of Southern California.
- Completed
- Registry status
- NA
- Development phase
- 121
- Enrollment target
NCT03642769 is a NA study that has completed, run by University of Southern California. The registered enrollment target is 121 participants.
The verdict
NCT03642769, a NA study, has completed, sponsored by University of Southern California.
- COMPLETED
- Registry status
- NA
- Development phase
- 121 participants
- Enrollment target
Study Summary
Acute pancreatitis is a common problem in the United States necessitating 275,000 hospital admissions per year, with resultant healthcare costs of approximately 2.5 billion USD annually. As numerous trials have failed to show a benefit to specific pharmacologic therapies in acute pancreatitis, the mainstay of treatment has been both supportive care and early, aggressive fluid resuscitation. Small randomized studies have shown conflicting results with regards to the influence of resuscitation fluid on outcomes in acute pancreatitis, necessitating a large randomized trial to clarify if fluid choice matters or not in the treatment of acute pancreatitis. The objective of this study is to assess the comparative efficacy of normal saline versus lactated ringer's solution in the management of acute pancreatitis. Patients presenting to the Los Angeles County Hospital with acute pancreatitis will be randomized to fluid resuscitation with NS or LR with volumes of fluid administered according to a pre-determined algorithm that will be the same for both treatment arms. The primary outcome of the study will be the change in SIRS prevalence from enrollment to 24 hours. Secondary outcomes will include the change in SIRS prevalence from enrollment to 48 hours and 72 hours, development of moderately severe or severe pancreatitis, change in PASS score, ICU admission, length of hospitalization, persistent pain or disability after discharge, and time of advancement to oral diet and discharge.
Interventions
- OTHER Fluid administration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 121 participants |
| Start Date | 2018-09-18 |
| Est. Completion | 2021-08-16 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03642769
The ClinicalTrials.gov registry entry for NCT03642769 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 121 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Southern California, which has 617 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Fluid administration is the first listed.
NCT03642769 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03642769 about?
NCT03642769 is a clinical study titled "Lactated Ringer's Versus Normal Saline for Acute Pancreatitis". Acute pancreatitis is a common problem in the United States necessitating 275,000 hospital admissions per year, with resultant healthcare costs of approximately 2.5 billion USD annually. As numerous trials have failed to show a benefit to specific pharmacologic therapies in acute pancreatitis, the m...
What is the current status of trial NCT03642769?
This trial is currently completed. It is a NA study. The enrollment target is 121 participants. The study started on 2018-09-18. Estimated completion is 2021-08-16.
What interventions are being tested in trial NCT03642769?
The interventions under investigation include: Fluid administration (OTHER).
Who is sponsoring clinical trial NCT03642769?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
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