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NCT03637751 · ClinicalTrials.gov registry record · NA
Temporal Genomics Mechanisms Underlying Disease and Aging
A NA study, sponsored by Penn State University.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT03637751: Completed NA study, sponsored by Penn State University.
NCT03637751 is a NA study that has completed, run by Penn State University. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03637751, a NA study, has completed, sponsored by Penn State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Given the salient role of early-life adversity and the resulting biological embedding in disease risk, there is a critical need to understand the mechanisms operating at multiple levels of analysis in order to promote effective clinical treatments and intervention efforts for survivors. An example for such an effort could be to utilize models of dynamic cellular markers as individual-level factors to account for variation in intervention response and clinical outcomes. Results of this study will lead to new knowledge about specific gene expression pathways in response to stress, and whether the response is moderated by previous exposure to early adversity, shorter telomere length (a marker of cellular aging) and self-report mental-health measures. Thus, the long-term effects of this study will advance our understanding on stress-related transcriptomic changes that play a downstream role in disease susceptibility and accelerated aging, with the goal of targeting specific pathways and genes for potential intervention studies and pharmacological treatments to reverse the effects of exposure to early adversity. For example, considering high failure rates for depression treatments, and in order to tailor individual interventions, identifying objective changes in stress-induced gene expression may help to predict intervention efficacy in clinical and non-clinical settings, as seen, for example, in breast and leukemia cancers. Thus, findings will have a range of impacts for basic science, intervention studies and clinical practice that will influence treatments to match the specific cellular processes operating within an individual.
Interventions
- BEHAVIORAL Behavioral
- BEHAVIORAL Control condition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2018-08-21 |
| Est. Completion | 2021-06-30 |
| Phase | NA |
What the finished NCT03637751 record still lists
NCT03637751 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Behavioral is the first listed.
NCT03637751 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03637751 about?
NCT03637751 is a clinical study titled "Temporal Genomics Mechanisms Underlying Disease and Aging". Given the salient role of early-life adversity and the resulting biological embedding in disease risk, there is a critical need to understand the mechanisms operating at multiple levels of analysis in order to promote effective clinical treatments and intervention efforts for survivors. An example f...
What is the current status of trial NCT03637751?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2018-08-21. Estimated completion is 2021-06-30.
What interventions are being tested in trial NCT03637751?
The interventions under investigation include: Behavioral (BEHAVIORAL), Control condition (BEHAVIORAL).
Who is sponsoring clinical trial NCT03637751?
This trial is sponsored by Penn State University, which has 219 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03637751's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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