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NCT03630159 · ClinicalTrials.gov registry record · Phase 1
Study of Tisagenlecleucel in Combination With Pembrolizumab in r/r Diffuse Large B-cell Lymphoma Patients
A Phase 1 study, sponsored by Novartis Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT03630159 is a Phase 1 study that has completed, run by Novartis Pharmaceuticals. The registered enrollment target is 12 participants.
The verdict
NCT03630159, a Phase 1 study, has completed, sponsored by Novartis Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
A multi-center, open-label, phase Ib study to evaluate the safety and efficacy of the administration of tisagenlecleucel in combination with pembrolizumab in patients with r/r DLBCL who have received 2 or more lines of systemic therapy, including an anti-CD20 and anthracycline based chemotherapy and having failed to or are not candidates for ASCT. The study will consist of 2 parts: dose timing selection part and expansion part.
Interventions
- DRUG Pembrolizumab
- BIOLOGICAL Tisagenlecleucel
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2018-10-09 |
| Est. Completion | 2021-07-20 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03630159
The ClinicalTrials.gov registry entry for NCT03630159 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 1,375 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT03630159 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03630159 about?
NCT03630159 is a clinical study titled "Study of Tisagenlecleucel in Combination With Pembrolizumab in r/r Diffuse Large B-cell Lymphoma Patients". A multi-center, open-label, phase Ib study to evaluate the safety and efficacy of the administration of tisagenlecleucel in combination with pembrolizumab in patients with r/r DLBCL who have received 2 or more lines of systemic therapy, including an anti-CD20 and anthracycline based chemotherapy and...
What is the current status of trial NCT03630159?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2018-10-09. Estimated completion is 2021-07-20.
What interventions are being tested in trial NCT03630159?
The interventions under investigation include: Pembrolizumab (DRUG), Tisagenlecleucel (BIOLOGICAL).
Who is sponsoring clinical trial NCT03630159?
This trial is sponsored by Novartis Pharmaceuticals, which has 1,375 total clinical trials registered on ClinicalTrials.gov.
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