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ACTIVE NOT RECRUITING Phase 2

Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors

NCT03610971 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine if adding Ruxolitinib to a Tyrone Kinase Inhibitor (TKI), prior to a second attempt at stopping a TKI will lead to prolonged treatment free remission (TFR).

Interventions

  • DRUG Ruxolitinib
  • DRUG BCR-ABL Tyrosine Kinase Inhibitor (TKI)

Study Locations (8)

New York

  • Roswell Park Comprehensive Cancer Center — Buffalo
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering — New York

Florida

  • H. Lee Moffitt Cancer Center and Research Institute — Tampa

Georgia

  • Emory -Winship Cancer Institute — Atlanta

New Jersey

  • Memorial Sloan Kettering - Bergen — Montvale

North Carolina

  • Duke University Hospital — Durham

Oregon

  • Oregon Health & Science University — Portland

Wisconsin

  • Froedtert Hospital & the Medical College of Wisconsin — Milwaukee

Trial Details

FieldValue
Enrollment Target 24 participants
Start Date 2019-11-19
Est. Completion 2026-10
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03610971

The ClinicalTrials.gov registry entry for NCT03610971 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is H. Lee Moffitt Cancer Center and Research Institute, which has 562 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Chronic Myeloid Leukemia, Chronic Phase appearing as the primary indexed condition, and to 2 interventions — of which Ruxolitinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03610971 reports 8 study locations spanning 7 distinct geographic areas — top geographies include New York, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03610971 about?

NCT03610971 is a clinical study titled "Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors". The purpose of this study is to determine if adding Ruxolitinib to a Tyrone Kinase Inhibitor (TKI), prior to a second attempt at stopping a TKI will lead to prolonged treatment free remission (TFR).

What is the current status of trial NCT03610971?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2019-11-19. Estimated completion is 2026-10.

What conditions does trial NCT03610971 study?

This clinical trial studies the following conditions: Chronic Myeloid Leukemia, Chronic Phase, Chronic Phase Chronic Myeloid Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03610971?

The interventions under investigation include: Ruxolitinib (DRUG), BCR-ABL Tyrosine Kinase Inhibitor (TKI) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03610971?

This trial is sponsored by H. Lee Moffitt Cancer Center and Research Institute, which has 562 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03610971 being conducted?

This trial has 8 study locations across Florida, Georgia, New Jersey, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial