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NCT03592238 · ClinicalTrials.gov registry record · NA
Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition
A NA study, sponsored by Northeastern University.
- Completed
- Registry status
- NA
- Development phase
- 297
- Enrollment target
NCT03592238: Completed NA study, sponsored by Northeastern University.
NCT03592238 is a NA study that has completed, run by Northeastern University. The registered enrollment target is 297 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (79% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03592238, a NA study, has completed, sponsored by Northeastern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 297 participants
- Enrollment target
Study Summary
Today's children have become increasingly inactive and unfit, with \>50% of children not meeting the recommended 60 min of moderate-to-vigorous physical activity. Previous research has suggested that acute aerobic exercise of moderate intensity was associated with improved cognition manifested by improved performance and increased P3 amplitude, a neuroelectric indicator that reflects the amount of attentional allocation, in tasks requiring cognitive control. While minimal evidence exists to support potential mechanisms underlying the transient effects of exercise on brain and cognition, research suggests that phasic changes in the locus coeruleus-norepinephrine (LC-NE) (as measured by salivary alpha amylase (sAA)) system are a potential mechanism for explaining the acute effect of exercise on brain and cognition. Accordingly, the aim of this study is to examine the mechanisms linking acute aerobic exercise to improved cognitive control as well as the underlying neuroelectrical activities in children, using electroencephalography (EEG) and event-related potentials (ERPs). We hope to gain a better understanding of the role of acute exercise and cognitive and brain health. The results from this study will help identify mechanisms linking acute exercise to enhanced cognitive performance in children. Our hypothesis is that exercise-induced phasic increases in sympathetic nervous system activity will mediate the effect of a single bout of exercise on brain function, cognition, and standardized achievement test performance.
Primary Outcome
P3 - ERP
Interventions
- OTHER Aerobic Exercise Intervention
- OTHER Trier Social Stress Test for Children
- OTHER Seated Rest
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 297 participants |
| Start Date | 2019-02-10 |
| Est. Completion | 2024-06-30 |
| Phase | NA |
What the finished NCT03592238 record still lists
NCT03592238 is an interventional study that assigns participants to a tested intervention. The registered 297 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (79% lower).
The record links to 0 conditions, and to 3 interventions - of which Aerobic Exercise Intervention is the first listed.
NCT03592238 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03592238 about?
NCT03592238 is a clinical study titled "Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition". Today's children have become increasingly inactive and unfit, with \>50% of children not meeting the recommended 60 min of moderate-to-vigorous physical activity. Previous research has suggested that acute aerobic exercise of moderate intensity was associated with improved cognition manifested by im...
What is the current status of trial NCT03592238?
This trial is currently completed. It is a NA study. The enrollment target is 297 participants. The study started on 2019-02-10. Estimated completion is 2024-06-30.
What interventions are being tested in trial NCT03592238?
The interventions under investigation include: Aerobic Exercise Intervention (OTHER), Trier Social Stress Test for Children (OTHER), Seated Rest (OTHER).
Who is sponsoring clinical trial NCT03592238?
This trial is sponsored by Northeastern University, which has 39 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03592238's enrollment target sits among peer trials
297 372nd of 2000 higher than 1,628 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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