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NCT03581942 · ClinicalTrials.gov registry record · Phase 1
Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL)
A Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
NCT03581942: Completed Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
NCT03581942 is a Phase 1 study that has completed, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 18 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03581942, a Phase 1 study, has completed, sponsored by Memorial Sloan Kettering Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
Study Summary
The purpose of this study is to test the safety of combined use of the study drugs, copanlisib and ibrutinib, in people with PCNSL.
Primary Outcome
The "3+3" design will be applied in the phase Ib portion of the trial.
Interventions
- DRUG Ibrutinib
- DRUG Copanlisib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2018-08-23 |
| Est. Completion | 2026-02-05 |
| Phase | Phase 1 |
What the finished NCT03581942 record still lists
NCT03581942 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 2 interventions - of which Ibrutinib is the first listed.
NCT03581942 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03581942 about?
NCT03581942 is a clinical study titled "Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL)". The purpose of this study is to test the safety of combined use of the study drugs, copanlisib and ibrutinib, in people with PCNSL.
What is the current status of trial NCT03581942?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2018-08-23. Estimated completion is 2026-02-05.
What interventions are being tested in trial NCT03581942?
The interventions under investigation include: Ibrutinib (DRUG), Copanlisib (DRUG).
Who is sponsoring clinical trial NCT03581942?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03581942's enrollment target sits among peer trials
18 1720th of 2000 higher than 216 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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