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NCT03577171 · ClinicalTrials.gov registry record · Phase 2
A Study Evaluating ABI-H0731+ Entecavir vs Entecavir Alone for the Treatment of Viremic HBeAg-positive Participants With Chronic Hepatitis B Virus Infection (cHBV)
A Phase 2 study, sponsored by Assembly Biosciences.
- Completed
- Registry status
- Phase 2
- Development phase
- 25
- Enrollment target
NCT03577171: Completed Phase 2 study, sponsored by Assembly Biosciences.
NCT03577171 is a Phase 2 study that has completed, run by Assembly Biosciences. The registered enrollment target is 25 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (81% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03577171, a Phase 2 study, has completed, sponsored by Assembly Biosciences.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 25 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if ABI-H0731 given in combination with a standard of care (SOC) entecavir (ETV) is safe and effective in participants with chronic hepatitis B infection (cHBV)
Primary Outcome
Hepatitis B virus (HBV) DNA was measured using COBAS TaqMan Version 2.0. The lower limit of quantitation (LLOQ) was 20 IU/mL and the limit of detection (LOD) was 10 IU/mL.
Interventions
- DRUG Placebo Oral Tablet
- DRUG ABI-H0731
- DRUG SOC ETV
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2018-06-19 |
| Est. Completion | 2019-06-21 |
| Phase | Phase 2 |
What the finished NCT03577171 record still lists
NCT03577171 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (81% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo Oral Tablet is the first listed.
NCT03577171 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03577171 about?
NCT03577171 is a clinical study titled "A Study Evaluating ABI-H0731+ Entecavir vs Entecavir Alone for the Treatment of Viremic HBeAg-positive Participants With Chronic Hepatitis B Virus Infection (cHBV)". The purpose of this study is to determine if ABI-H0731 given in combination with a standard of care (SOC) entecavir (ETV) is safe and effective in participants with chronic hepatitis B infection (cHBV)
What is the current status of trial NCT03577171?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 25 participants. The study started on 2018-06-19. Estimated completion is 2019-06-21.
What interventions are being tested in trial NCT03577171?
The interventions under investigation include: Placebo Oral Tablet (DRUG), ABI-H0731 (DRUG), SOC ETV (DRUG).
Who is sponsoring clinical trial NCT03577171?
This trial is sponsored by Assembly Biosciences, which has 11 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03577171's enrollment target sits among peer trials
25 1719th of 2000 higher than 245 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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