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NCT03576781 · ClinicalTrials.gov registry record · Early Phase 1
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
A Early Phase 1 study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 70
- Enrollment target
NCT03576781: Completed Early Phase 1 study, sponsored by Medical University of South Carolina.
NCT03576781 is a Early Phase 1 study that has completed, run by Medical University of South Carolina. The registered enrollment target is 70 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (32% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03576781, a Early Phase 1 study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 70 participants
- Enrollment target
Study Summary
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription opiates. Repetitive TMS is a non-invasive tool that uses magnetic pulses to temporarily stimulate specific brain areas. This study will test whether rTMS over different locations of the prefrontal cortex can produce a reduction in an individuals perception of pain and how the brain responds to pain. Participants will be randomized to receive either sham-rTMS, or one of two real rTMS treatments. Brain imaging, behavioral assessments, and pain assessments will be collected both immediately before and after rTMS.
Primary Outcome
The effect of real vs. sham iTBS to the left DLPFC vs. real vs. sham cTBS to the left MPFC as a tool to modulate the brain response to pain will be assessed by comparing the brain activity in the executive circuit and limbic circuit before and after TMS.
Interventions
- DEVICE Sham cTBS
- DEVICE Sham iTBS
- DEVICE Real iTBS
- DEVICE Real cTBS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2017-02-09 |
| Est. Completion | 2019-11-12 |
| Phase | Early Phase 1 |
What the finished NCT03576781 record still lists
NCT03576781 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (32% higher).
The record links to 0 conditions, and to 4 interventions - of which Sham cTBS is the first listed.
NCT03576781 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03576781 about?
NCT03576781 is a clinical study titled "Developing rTMS Treatment Strategies for Pain in Opiate Dependence". The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription opiates. Repetitive TMS is a non-invasive tool that uses magnetic puls...
What is the current status of trial NCT03576781?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 70 participants. The study started on 2017-02-09. Estimated completion is 2019-11-12.
What interventions are being tested in trial NCT03576781?
The interventions under investigation include: Sham cTBS (DEVICE), Sham iTBS (DEVICE), Real iTBS (DEVICE), Real cTBS (DEVICE).
Who is sponsoring clinical trial NCT03576781?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03576781's enrollment target sits among peer trials
70 339th of 2000 higher than 1,647 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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