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NCT03550885 · ClinicalTrials.gov registry record · NA
Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk
A NA study, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- NA
- Development phase
- 15
- Enrollment target
NCT03550885: Completed NA study, sponsored by University of Illinois at Chicago.
NCT03550885 is a NA study that has completed, run by University of Illinois at Chicago. The registered enrollment target is 15 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03550885, a NA study, has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 15 participants
- Enrollment target
Study Summary
Determine in the context of a controlled crossover diet-intervention trial the role of taurocholic acid metabolism by gut bacteria in African American subjects at elevated risk for colorectal cancer (CRC). Two isocaloric diets, an animal-based diet high in taurine and saturated fat (HT-HSAT) and a plant-based, low in taurine and low saturated fat (LT-LSAT) will be used to determine the extent to which the relationship between diet (independent variable) and mucosal markers of CRC risk including epithelial proliferation, oxidative stress, DNA damage, and primary and secondary bile acid pools and biomarkers of inflammation (dependent variables) is explained by the abundance of sulfidogenic bacteria and hydrogen sulfide (H2S) concentrations \&/or deoxycholic acid (DCA) and DCA-producing bacteria clostridium scindens (mediator variables).
Primary Outcome
Mucosal abundance of bacterial genes associated with sulfur and bile acid metabolism will be measured by quantitative polymerase chain reaction of 16S rRNA and functional genes with biopsy DNA.
Interventions
- OTHER High taurine and saturated fat diet
- OTHER Low in taurine and saturated fat diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2018-08-01 |
| Est. Completion | 2021-12-01 |
| Phase | NA |
What the finished NCT03550885 record still lists
NCT03550885 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which High taurine and saturated fat diet is the first listed.
NCT03550885 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03550885 about?
NCT03550885 is a clinical study titled "Diet Modulation of Bacterial Sulfur and Bile Acid Metabolism and Colon Cancer Risk". Determine in the context of a controlled crossover diet-intervention trial the role of taurocholic acid metabolism by gut bacteria in African American subjects at elevated risk for colorectal cancer (CRC). Two isocaloric diets, an animal-based diet high in taurine and saturated fat (HT-HSAT) and a p...
What is the current status of trial NCT03550885?
This trial is currently completed. It is a NA study. The enrollment target is 15 participants. The study started on 2018-08-01. Estimated completion is 2021-12-01.
What interventions are being tested in trial NCT03550885?
The interventions under investigation include: High taurine and saturated fat diet (OTHER), Low in taurine and saturated fat diet (OTHER).
Who is sponsoring clinical trial NCT03550885?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03550885's enrollment target sits among peer trials
15 1881st of 2000 higher than 92 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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