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NCT03537937 · ClinicalTrials.gov registry record · NA
Pragmatic Investigation of optimaL Oxygen Targets Trial
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 2,541
- Enrollment target
NCT03537937 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 2,541 participants.
The verdict
NCT03537937, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 2,541 participants
- Enrollment target
Study Summary
Mechanical ventilation of ICU patients universally involves titration of the fraction of inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU practice, however, the optimal SpO2 target remains unknown. Current guidelines offer divergent recommendations as to the optimal SpO2 target. Therefore, we propose a 2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%; range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target (98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical ventilation.
Interventions
- OTHER Lower SpO2 Target
- OTHER Intermediate SpO2 Target
- OTHER Higher SpO2 Target
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,541 participants |
| Start Date | 2018-07-01 |
| Est. Completion | 2022-01-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03537937
The ClinicalTrials.gov registry entry for NCT03537937 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 2,541 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Lower SpO2 Target is the first listed.
NCT03537937 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03537937 about?
NCT03537937 is a clinical study titled "Pragmatic Investigation of optimaL Oxygen Targets Trial". Mechanical ventilation of ICU patients universally involves titration of the fraction of inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU practice, however, the optimal SpO2 target remains unknown. Current guidelines offer divergent recommendations as to t...
What is the current status of trial NCT03537937?
This trial is currently completed. It is a NA study. The enrollment target is 2,541 participants. The study started on 2018-07-01. Estimated completion is 2022-01-31.
What interventions are being tested in trial NCT03537937?
The interventions under investigation include: Lower SpO2 Target (OTHER), Intermediate SpO2 Target (OTHER), Higher SpO2 Target (OTHER).
Who is sponsoring clinical trial NCT03537937?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
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