Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03509012 · ClinicalTrials.gov registry record · Phase 1
Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors
A Phase 1 study, sponsored by AstraZeneca.
- Completed
- Registry status
- Phase 1
- Development phase
- 105
- Enrollment target
NCT03509012: Completed Phase 1 study, sponsored by AstraZeneca.
NCT03509012 is a Phase 1 study that has completed, run by AstraZeneca. The registered enrollment target is 105 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03509012, a Phase 1 study, has completed, sponsored by AstraZeneca.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 105 participants
- Enrollment target
Study Summary
This is an open-label, multicenter, phase I study to evaluate the safety and tolerability of durvalumab ± tremelimumab in combination with chemoradiation in patients with advanced solid tumors
Interventions
- DRUG Durvalumab
- DRUG Tremelimumab
- DRUG Cisplatin (dose level 4)
- DRUG Cisplatin (dose level 3)
- DRUG Carboplatin (dose level 1)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2018-05-02 |
| Est. Completion | 2025-01-08 |
| Phase | Phase 1 |
What the finished NCT03509012 record still lists
NCT03509012 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% higher).
The record links to 0 conditions, and to 5 interventions - of which Durvalumab is the first listed.
NCT03509012 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03509012 about?
NCT03509012 is a clinical study titled "Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors". This is an open-label, multicenter, phase I study to evaluate the safety and tolerability of durvalumab ± tremelimumab in combination with chemoradiation in patients with advanced solid tumors
What is the current status of trial NCT03509012?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 105 participants. The study started on 2018-05-02. Estimated completion is 2025-01-08.
What interventions are being tested in trial NCT03509012?
The interventions under investigation include: Durvalumab (DRUG), Tremelimumab (DRUG), Cisplatin (dose level 4) (DRUG), Cisplatin (dose level 3) (DRUG), Carboplatin (dose level 1) (DRUG).
Who is sponsoring clinical trial NCT03509012?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03509012's enrollment target sits among peer trials
105 533rd of 2000 higher than 1,465 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03372317 · 105 participants
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
- NCT04253964 · 105 participants · Phase 2
Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy
- NCT04742452 · 105 participants · NA
Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
- NCT04875429 · 105 participants · NA
Zenith® Fenestrated+ Clinical Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI