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NCT03480737 · ClinicalTrials.gov registry record · NA
Brain Stimulation for Working Memory Deficits in Adolescents With ADHD
A NA study, sponsored by Bradley Hospital.
- Completed
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT03480737: Completed NA study, sponsored by Bradley Hospital.
NCT03480737 is a NA study that has completed, run by Bradley Hospital. The registered enrollment target is 14 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03480737, a NA study, has completed, sponsored by Bradley Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
Working memory (WM) is the foundational cognitive control process of holding information 'in mind' to execute goal-directed behaviors. WM deficits are an established component of ADHD. Despite being one of the strongest predictors of poor clinical and functional outcomes in pediatric mental health, there remains a dearth of available treatments for WM deficits. Non-invasive brain stimulation hold tremendous promise in transforming psychiatry, as it takes a "brain-first" approach to treatment. The dorsolateral prefrontal cortex (DLPFC) is the known structural foundation of WM, and the interaction between slow and fast brain waves (i.e., "theta-gamma coupling \[TGC\]") is a neural, functional foundation of WM. Thus, the DLPFC and TGC are potential brain-based targets for the modulation of WM with brain stimulation. Intermittent theta burst stimulation (iTBS) is a novel paradigm that applies a three-minute dose of stimulation to the DLPFC at an intensity that directly mimics TGC dynamics. The objective of this study is to test whether iTBS can enhance dysfunctional brain activity that causes working memory deficits. iTBS will be tested compared to standard or traditional transcranial magnetic stimulation (TMS), called 10 Hz TMS. It will also be compared to sham or fake TMS. Each participant receives a single session of each of these types of TMS. EEG will record neural activity during a working memory test immediately before and after each TMS session. If this study shows TMS can enhance dysfunctional brain activity, the next step will be to conduct a clinical trial to test if TMS can lead to a sustained, positive effect on working memory deficits.
Interventions
- DEVICE Magstim Super Rapid2 stimulator, 10 Hz condition
- DEVICE Magstim Super Rapid2 stimulator, Sham condition
- DEVICE Magstim Super Rapid2 stimulator, iTBS condition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2019-11-01 |
| Est. Completion | 2023-03-30 |
| Phase | NA |
What the finished NCT03480737 record still lists
NCT03480737 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which Magstim Super Rapid2 stimulator, 10 Hz condition is the first listed.
NCT03480737 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03480737 about?
NCT03480737 is a clinical study titled "Brain Stimulation for Working Memory Deficits in Adolescents With ADHD". Working memory (WM) is the foundational cognitive control process of holding information 'in mind' to execute goal-directed behaviors. WM deficits are an established component of ADHD. Despite being one of the strongest predictors of poor clinical and functional outcomes in pediatric mental health, ...
What is the current status of trial NCT03480737?
This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2019-11-01. Estimated completion is 2023-03-30.
What interventions are being tested in trial NCT03480737?
The interventions under investigation include: Magstim Super Rapid2 stimulator, 10 Hz condition (DEVICE), Magstim Super Rapid2 stimulator, Sham condition (DEVICE), Magstim Super Rapid2 stimulator, iTBS condition (DEVICE).
Who is sponsoring clinical trial NCT03480737?
This trial is sponsored by Bradley Hospital, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03480737's enrollment target sits among peer trials
14 1909th of 2000 higher than 90 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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