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NCT03446651 · ClinicalTrials.gov registry record · Early Phase 1
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
A Early Phase 1 study, sponsored by Yale University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 50
- Enrollment target
NCT03446651: Completed Early Phase 1 study, sponsored by Yale University.
NCT03446651 is a Early Phase 1 study that has completed, run by Yale University. The registered enrollment target is 50 participants, roughly in line with the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03446651, a Early Phase 1 study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 50 participants
- Enrollment target
Study Summary
The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.
Primary Outcome
Volumex is albumin labeled with the iodine isotope I-131 and is an FDA-approved method used to determine total blood volume. A linear mixed effect model will be used to analyze the trial with class variables of time and treatment group. Daily measures of blood collection will be compared across the 7 day collection period between intervention and placebo arms.
Interventions
- OTHER Placebo
- DRUG Lysine Chloride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2018-07-12 |
| Est. Completion | 2022-09-07 |
| Phase | Early Phase 1 |
What the finished NCT03446651 record still lists
NCT03446651 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, roughly in line with the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03446651 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03446651 about?
NCT03446651 is a clinical study titled "Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure". The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.
What is the current status of trial NCT03446651?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2018-07-12. Estimated completion is 2022-09-07.
What interventions are being tested in trial NCT03446651?
The interventions under investigation include: Placebo (OTHER), Lysine Chloride (DRUG).
Who is sponsoring clinical trial NCT03446651?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03446651's enrollment target sits among peer trials
50 493rd of 2000 higher than 1,468 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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