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NCT03445390 · ClinicalTrials.gov registry record · Phase 4
The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy
A Phase 4 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 4
- Development phase
- 27
- Enrollment target
NCT03445390: Completed Phase 4 study, sponsored by Stanford University.
NCT03445390 is a Phase 4 study that has completed, run by Stanford University. The registered enrollment target is 27 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03445390, a Phase 4 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 27 participants
- Enrollment target
Study Summary
The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. If the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid related side effects such as nausea/vomiting, pruritus, and sedation. While numerous other studies have failed to show a benefit of IV acetaminophen after neurosurgical procedures, we are studying the administration of 1 g in two doses over the course of the operation.
Primary Outcome
From nursing records how much opioid was administered to each patient post-operatively. Opioid use was measured in micrograms (ug) of fentanyl.
Interventions
- DRUG Placebo
- DRUG Acetaminophen
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2014-05-01 |
| Est. Completion | 2017-11-01 |
| Phase | Phase 4 |
What the finished NCT03445390 record still lists
NCT03445390 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03445390 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03445390 about?
NCT03445390 is a clinical study titled "The Effect of Intravenous Acetaminophen on Post-Operative Pain After Craniotomy". The purpose of the study is to determine the efficacy of IV acetaminophen when administered to neurosurgical patients at the beginning and end of their surgery. If the result is improved pain control with less opioid consumption postoperatively, then those patients may also experience less opioid re...
What is the current status of trial NCT03445390?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 27 participants. The study started on 2014-05-01. Estimated completion is 2017-11-01.
What interventions are being tested in trial NCT03445390?
The interventions under investigation include: Placebo (DRUG), Acetaminophen (DRUG).
Who is sponsoring clinical trial NCT03445390?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03445390's enrollment target sits among peer trials
27 1651st of 2000 higher than 346 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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