Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Extended Access of Momelotinib in Adults With Myelofibrosis

NCT03441113 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to provide extended access and assess long-term safety of momelotinib (MMB) in participants with primary myelofibrosis (PMF) or post-polycythemia vera or post-essential thrombocythemia myelofibrosis (Post-PV/ET MF) enrolled in studies GS-US-352-0101 (NCT01969838), GS-US-352-1214 (NCT02101268), GS-US-352-1154 (NCT02124746), SRA-MMB-301 who are currently receiving treatment with MMB (available as 50mg,100 mg, 150 mg and 200 mg tablets) and have not experienced progression of disease. The secondary objective is to assess overall survival (OS) and leukemia free survival (LFS) in all subjects.

Interventions

  • DRUG MMB

Study Locations (20)

Florida

  • GSK Investigational Site — Jacksonville
  • Mayo Clinic Florida — Jacksonville
  • GSK Investigational Site — Tampa
  • Moffitt Cancer Center — Tampa

California

  • IC Irvine Health — Orange
  • GSK Investigational Site — Stanford
  • Stanford Hospital and Clinics — Stanford

Colorado

  • GSK Investigational Site — Aurora
  • University of Colorado Cancer Center — Aurora

Georgia

  • GSK Investigational Site — Atlanta
  • Winship Cancer Institute, Emory University — Atlanta

Maryland

  • GSK Investigational Site — Baltimore
  • Saint Agnes Hospital — Baltimore

Massachusetts

  • Dana-Farber Cancer Institute (DFCI) — Boston
  • GSK Investigational Site — Boston

Minnesota

  • GSK Investigational Site — Rochester
  • Mayo Clinic - Department of Hematology — Rochester

Missouri

  • Washington University School of Medicine Siteman Cancer Center — St Louis
  • GSK Investigational Site — St Louis

Trial Details

FieldValue
Enrollment Target 237 participants
Start Date 2018-05-03
Est. Completion 2026-12-31
Phase Phase 2

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03441113

The ClinicalTrials.gov registry entry for NCT03441113 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 237 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Neoplasms appearing as the primary indexed condition, and to 1 intervention — of which MMB is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03441113 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03441113 about?

NCT03441113 is a clinical study titled "Extended Access of Momelotinib in Adults With Myelofibrosis". The primary objective of this study is to provide extended access and assess long-term safety of momelotinib (MMB) in participants with primary myelofibrosis (PMF) or post-polycythemia vera or post-essential thrombocythemia myelofibrosis (Post-PV/ET MF) enrolled in studies GS-US-352-0101 (NCT0196983...

What is the current status of trial NCT03441113?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 237 participants. The study started on 2018-05-03. Estimated completion is 2026-12-31.

What conditions does trial NCT03441113 study?

This clinical trial studies the following conditions: Neoplasms, Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), Post-essential Thrombocythemia Myelofibrosis (Post-ET MF). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03441113?

The interventions under investigation include: MMB (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03441113?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03441113 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial