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Study of BGB-290 or Placebo in Participants With Advanced or Inoperable Gastric Cancer
NCT03427814 · View on ClinicalTrials.gov ↗
Study Summary
This study enrolled participants with previously-treated advanced or inoperable gastric cancer who have responded to first line platinum therapy into two treatment arms. In Arm A participants received BGB-290; in Arm B participants received placebo. The purpose of this study is to show that BGB-290 (pamiparib) (versus placebo) will improve progression-free survival (PFS) in participants with advanced or inoperable gastric cancer.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Pamiparib
Study Locations (20)
Guangdong
- Sun Yat Sen University Cancer Center — Guangzhou
- Nanfang Hospital of Southern Medical University — Guangzhou
- Cancer Hospital of Shantou University Medical College — Shantou
Florida
- Miami Cancer Institute — Miami
- Scri Florida Cancer Specialist East — West Palm Beach
Victoria
- Monash Health — Clayton
- Ballarat Oncology and Haematology Services — Wendouree
Other
- Az Sint Jan Brugge — Bruges
- University Hospitals Leuven — Leuven
Indiana
- Goshen Center For Cancer Care — Goshen
Kansas
- Cancer Center of Kansas — Wichita
Kentucky
- Norton Cancer Institute — Louisville
North Carolina
- Novant Health Hematology Charlotte — Charlotte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 136 participants |
| Start Date | 2018-07-03 |
| Est. Completion | 2023-01-03 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03427814
The ClinicalTrials.gov registry entry for NCT03427814 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 136 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced or Inoperable Gastric Cancer appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03427814 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Guangdong, Florida, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03427814 about?
NCT03427814 is a clinical study titled "Study of BGB-290 or Placebo in Participants With Advanced or Inoperable Gastric Cancer". This study enrolled participants with previously-treated advanced or inoperable gastric cancer who have responded to first line platinum therapy into two treatment arms. In Arm A participants received BGB-290; in Arm B participants received placebo. The purpose of this study is to show that BGB-290 ...
What is the current status of trial NCT03427814?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 136 participants. The study started on 2018-07-03. Estimated completion is 2023-01-03.
What conditions does trial NCT03427814 study?
This clinical trial studies the following conditions: Advanced or Inoperable Gastric Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03427814?
The interventions under investigation include: Placebo (DRUG), Pamiparib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03427814?
This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03427814 being conducted?
This trial has 20 study locations across Florida, Indiana, Kansas, Kentucky, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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