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NCT03421808 · ClinicalTrials.gov registry record · Phase 2
EEG Synchronized TMS Trial for Depression
A Phase 2 study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 34
- Enrollment target
NCT03421808 is a Phase 2 study that has completed, run by Medical University of South Carolina. The registered enrollment target is 34 participants.
The verdict
NCT03421808, a Phase 2 study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 34 participants
- Enrollment target
Study Summary
Daily prefrontal TMS for depression, as developed by the PI, involves delivering TMS pulses to the prefrontal cortex and not assessing what the actual EEG phase is of the person's brain. In cardiology, in order to stimulate the heart effectively, one has to know the rhythm and phase of the heartbeat in order to perform cardioversion. The investigators wonder if it is important to time the brain stimulation with the phase of the person's brain. The brain has definite rhythms, and cycles through being excited or resting. A common EEG rhythm is alpha frequency. Theoretically, the effect of the TMS pulse might be diminished if it was delivered when the brain was temporarily cycling into an off state. In the r21 part of this grant, the investigators designed and constructed a combined TMS/EEG/fMRI system. With that equipment the investigators found that TMS pulses have different effects deeper in the brain as a function of the EEG alpha phase. Pulses delivered during a rising phase produce larger blood flow changes deeper in the brain than do pulses delivered during a falling phase. In the R33 phase of the grant the investigators now take that idea into a small clinical trial in depression to test if synchronized pulses have a larger clinical effect than do non-synchronized pulses.
Interventions
- DEVICE Transcranial Magnetic Stimulation (TMS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2018-11-30 |
| Est. Completion | 2024-01-15 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03421808
The ClinicalTrials.gov registry entry for NCT03421808 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Transcranial Magnetic Stimulation (TMS) is the first listed.
NCT03421808 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03421808 about?
NCT03421808 is a clinical study titled "EEG Synchronized TMS Trial for Depression". Daily prefrontal TMS for depression, as developed by the PI, involves delivering TMS pulses to the prefrontal cortex and not assessing what the actual EEG phase is of the person's brain. In cardiology, in order to stimulate the heart effectively, one has to know the rhythm and phase of the heartbeat...
What is the current status of trial NCT03421808?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 34 participants. The study started on 2018-11-30. Estimated completion is 2024-01-15.
What interventions are being tested in trial NCT03421808?
The interventions under investigation include: Transcranial Magnetic Stimulation (TMS) (DEVICE).
Who is sponsoring clinical trial NCT03421808?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
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