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NCT03384446 · ClinicalTrials.gov registry record · NA
Dental Hygiene and Peri-Implant Tissues Homeostasis
A NA study, sponsored by University of Washington.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT03384446: Completed NA study, sponsored by University of Washington.
NCT03384446 is a NA study that has completed, run by University of Washington. The registered enrollment target is 34 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03384446, a NA study, has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Dental implants have revolutionized the field of dentistry, providing improvements in function and esthetics. They are not, however, without risks. Bone loss around implants (i.e. periimplantitis) is an emerging public health concern. Untreated, peri-implantitis leads to implant loss and jawbone defects. Nonetheless, existing therapies have failed to show long-term efficacy. The pathogenesis of peri-implantitis is believed to be of bacterial etiology similar to periodontal disease. Therefore, existing treatments duplicate strategies for the treatment of natural teeth. However, the titanium (Ti) surface of implants is quite dissimilar to teeth. Recent work from our lab has demonstrated that peri-implantitis is associated with increased release of Ti particles around implants. These findings suggest that treatments targeting periimplantitis must be designed around Ti material properties. A gap in knowledge exists regarding the potential triggers of increased Ti dissolution from the implant surface and the mechanisms by which Ti dissolution products amplify peri-implant inflammation. The aim of this study is to determine if the use of tooth-driven treatment approaches increase Ti in the submucosal plaque.
Primary Outcome
The primary outcome of the clinical trial will be titanium dissolution in periimplant plaque at 8 weeks following treatment quantified using inductively coupled mass spectrometry (ICMS)
Interventions
- OTHER Tooth-borne treatment
- OTHER Implant-specific treatment
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2017-11-22 |
| Est. Completion | 2023-06-10 |
| Phase | NA |
What the finished NCT03384446 record still lists
NCT03384446 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Tooth-borne treatment is the first listed.
NCT03384446 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03384446 about?
NCT03384446 is a clinical study titled "Dental Hygiene and Peri-Implant Tissues Homeostasis". Dental implants have revolutionized the field of dentistry, providing improvements in function and esthetics. They are not, however, without risks. Bone loss around implants (i.e. periimplantitis) is an emerging public health concern. Untreated, peri-implantitis leads to implant loss and jawbone def...
What is the current status of trial NCT03384446?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2017-11-22. Estimated completion is 2023-06-10.
What interventions are being tested in trial NCT03384446?
The interventions under investigation include: Tooth-borne treatment (OTHER), Implant-specific treatment (OTHER).
Who is sponsoring clinical trial NCT03384446?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03384446's enrollment target sits among peer trials
34 1570th of 2000 higher than 427 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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