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NCT03371979 · ClinicalTrials.gov registry record · Phase 1
Pegzilarginase and Pembrolizumab for Extensive Disease Small Cell Lung Cancer
A Phase 1 study, sponsored by Aeglea Biotherapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 68
- Enrollment target
NCT03371979: Completed Phase 1 study, sponsored by Aeglea Biotherapeutics.
NCT03371979 is a Phase 1 study that has completed, run by Aeglea Biotherapeutics. The registered enrollment target is 68 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03371979, a Phase 1 study, has completed, sponsored by Aeglea Biotherapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 68 participants
- Enrollment target
Study Summary
The main purpose of this Phase 1/2 study is to determine the safety and efficacy of pegzilarginase in combination with pembrolizumab in patients with ED-SCLC who have relapsed or progressive disease on or within 6 months of platinum-based chemotherapy.
Primary Outcome
1\. Number of participants experiencing treatment-related adverse events as assessed by CTCAE v4.0.
Interventions
- DRUG Pembrolizumab
- DRUG Pegzilarginase
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2017-12-21 |
| Est. Completion | 2021-01-01 |
| Phase | Phase 1 |
What the finished NCT03371979 record still lists
NCT03371979 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT03371979 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03371979 about?
NCT03371979 is a clinical study titled "Pegzilarginase and Pembrolizumab for Extensive Disease Small Cell Lung Cancer". The main purpose of this Phase 1/2 study is to determine the safety and efficacy of pegzilarginase in combination with pembrolizumab in patients with ED-SCLC who have relapsed or progressive disease on or within 6 months of platinum-based chemotherapy.
What is the current status of trial NCT03371979?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 68 participants. The study started on 2017-12-21. Estimated completion is 2021-01-01.
What interventions are being tested in trial NCT03371979?
The interventions under investigation include: Pembrolizumab (DRUG), Pegzilarginase (DRUG).
Who is sponsoring clinical trial NCT03371979?
This trial is sponsored by Aeglea Biotherapeutics, which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03371979's enrollment target sits among peer trials
68 776th of 2000 higher than 1,219 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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