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NCT03362515 · ClinicalTrials.gov registry record · Phase 2
Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
A Phase 2 study, sponsored by Thomas Jefferson University.
- Terminated
- Registry status
- Phase 2
- Development phase
- 18
- Enrollment target
NCT03362515: Clinical Trial Phase 2 study, sponsored by Thomas Jefferson University.
NCT03362515 is a Phase 2 study that was terminated before completion, run by Thomas Jefferson University. The registered enrollment target is 18 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (86% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03362515, a Phase 2 study, was terminated before completion, sponsored by Thomas Jefferson University.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 18 participants
- Enrollment target
Study Summary
Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal polyposis following sinus surgery. This project aims to further investigate that claim through a blinded randomized controlled clinical trial following patients who undergo functional sinus surgery for chronic rhinosinusitis with sinonasal polyposis by randomly assigning participants to receive topical furosemide versus placebo nasal spray for 2 months post operatively. Outcomes would be compared at 6 months through endoscopic grading scores using Lund Kennedy and Meltzer scores as well as Sino-Nasal Outcome Test (SNOT-22) scores to measure the rate and degree of recurrence and impact on symptoms in the treatment group versus placebo.
Primary Outcome
Nasal and paranasal polyposis based on endoscopic grading through Lund Kennedy score to measure the rate and degree of recurrence.
Interventions
- DRUG Placebo
- DRUG Furosemide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2017-12-01 |
| Est. Completion | 2022-04-14 |
| Phase | Phase 2 |
Why NCT03362515 stopped before completion
NCT03362515 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (86% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03362515 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03362515 about?
NCT03362515 is a clinical study titled "Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide". Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal polyposis following sinus surgery. This project aims to further investigate that claim through a blinded randomized controlled clinical trial following patients who undergo functional sinus surgery for chroni...
What is the current status of trial NCT03362515?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 18 participants. The study started on 2017-12-01. Estimated completion is 2022-04-14.
What interventions are being tested in trial NCT03362515?
The interventions under investigation include: Placebo (DRUG), Furosemide (DRUG).
Who is sponsoring clinical trial NCT03362515?
This trial is sponsored by Thomas Jefferson University, which has 292 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03362515's enrollment target sits among peer trials
18 1898th of 2000 higher than 98 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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