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NCT03341754 · ClinicalTrials.gov registry record · Phase 1
Trial to Evaluate the Safety, Immunogenicity, and Efficacy of Malaria Infection in Malaria Naïve Adults
A Phase 1 study, sponsored by U.S. Army Medical Research and Development Command.
- Completed
- Registry status
- Phase 1
- Development phase
- 52
- Enrollment target
NCT03341754: Completed Phase 1 study, sponsored by U.S. Army Medical Research and Development Command.
NCT03341754 is a Phase 1 study that has completed, run by U.S. Army Medical Research and Development Command. The registered enrollment target is 52 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03341754, a Phase 1 study, has completed, sponsored by U.S. Army Medical Research and Development Command.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 52 participants
- Enrollment target
Study Summary
This is a study designed to assess the safety, tolerability, immunogenicity, and protective efficacy of 2 heterologous prime-boost vaccine regimens in healthy, malaria naïve adults. The study will include 2 vaccine groups and an infectivity control (IC) group consisting of non-immunized subjects. Subjects to be immunized will be randomly assigned to one of two vaccine groups.
Primary Outcome
Occurrence of Serious Adverse Events following immunization through day 7 after each immunization
Interventions
- BIOLOGICAL D/ChAd63-CA
- BIOLOGICAL D/ChAd63-CAT
- OTHER Infectivity Control (IC) Group
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2018-09-15 |
| Est. Completion | 2020-03-23 |
| Phase | Phase 1 |
What the finished NCT03341754 record still lists
NCT03341754 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 52 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (13% lower).
The record links to 0 conditions, and to 3 interventions - of which D/ChAd63-CA is the first listed.
NCT03341754 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03341754 about?
NCT03341754 is a clinical study titled "Trial to Evaluate the Safety, Immunogenicity, and Efficacy of Malaria Infection in Malaria Naïve Adults". This is a study designed to assess the safety, tolerability, immunogenicity, and protective efficacy of 2 heterologous prime-boost vaccine regimens in healthy, malaria naïve adults. The study will include 2 vaccine groups and an infectivity control (IC) group consisting of non-immunized subjects. Su...
What is the current status of trial NCT03341754?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2018-09-15. Estimated completion is 2020-03-23.
What interventions are being tested in trial NCT03341754?
The interventions under investigation include: D/ChAd63-CA (BIOLOGICAL), D/ChAd63-CAT (BIOLOGICAL), Infectivity Control (IC) Group (OTHER).
Who is sponsoring clinical trial NCT03341754?
This trial is sponsored by U.S. Army Medical Research and Development Command, which has 77 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03341754's enrollment target sits among peer trials
52 956th of 2000 higher than 1,032 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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