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NCT03322449 · ClinicalTrials.gov registry record · NA
APOA2 Gene, Diet, Inflammation and Gut Health
A NA study, sponsored by Tufts University.
- Terminated
- Registry status
- NA
- Development phase
- 37
- Enrollment target
NCT03322449: Clinical Trial NA study, sponsored by Tufts University.
NCT03322449 is a NA study that was terminated before completion, run by Tufts University. The registered enrollment target is 37 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03322449, a NA study, was terminated before completion, sponsored by Tufts University.
- TERMINATED
- Registry status
- NA
- Development phase
- 37 participants
- Enrollment target
Study Summary
Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response to unhealthy diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The apolipoprotein A2 (APOA2) gene may either put individuals at risk for or protect from obesity in the presence of certain fats in food. The main purpose of this four-week study is to examine diet induced gene-nutrient interaction, with a focus on gut health, gut microbiota and inflammation in individuals who have either the CC or the TT form within a specific variant of the APOA2 Gene. The (2) one-week study diets, one plant based and the other animal based are separated by a (1) week return to your regular habitual without probiotic or prebiotic food products.
Primary Outcome
The response of plasma metabolites related to tryptophan metabolism to diets differing in saturated fat and prebiotics content (animal-based diet versus plant-based diet) will vary in individuals carrying CC (n=20) and TT (n=20) genotypes at the common APOA2 -265T\>C single nucleotide polymorphism (SNP)
Interventions
- OTHER Animal Diet
- OTHER Plant Diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2017-10-13 |
| Est. Completion | 2020-04-30 |
| Phase | NA |
Why NCT03322449 stopped before completion
NCT03322449 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Animal Diet is the first listed.
NCT03322449 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03322449 about?
NCT03322449 is a clinical study titled "APOA2 Gene, Diet, Inflammation and Gut Health". Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response to unhealthy diets can increase an individual's risk, shifting the individual from health toward the development of chronic disease. The apolipoprotein A2 (APOA2) gene may eithe...
What is the current status of trial NCT03322449?
This trial is currently terminated. It is a NA study. The enrollment target is 37 participants. The study started on 2017-10-13. Estimated completion is 2020-04-30.
What interventions are being tested in trial NCT03322449?
The interventions under investigation include: Animal Diet (OTHER), Plant Diet (OTHER).
Who is sponsoring clinical trial NCT03322449?
This trial is sponsored by Tufts University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03322449's enrollment target sits among peer trials
37 1540th of 2000 higher than 460 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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