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NCT03319771 · ClinicalTrials.gov registry record · NA
Exercise and Learning and Memory in Multiple Sclerosis
A NA study, sponsored by University of Alabama at Birmingham.
- Terminated
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT03319771: Clinical Trial NA study, sponsored by University of Alabama at Birmingham.
NCT03319771 is a NA study that was terminated before completion, run by University of Alabama at Birmingham. The registered enrollment target is 14 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03319771, a NA study, was terminated before completion, sponsored by University of Alabama at Birmingham.
- TERMINATED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
The two primary study objectives involve examining the effects of treadmill walking exercise training versus stretching-and-toning activities on the primary and secondary outcomes. Specific Aim 1: The first specific aim is to examine the effects of 3-months of treadmill walking exercise training compared with an active control condition on learning and memory outcomes in fully-ambulatory persons with MS who have impairment in learning new information. We hypothesize that those who undergo treadmill walking exercise training will demonstrate improvements in learning and memory relative to those who undergo stretching-and-toning activities. Specific Aim 2: The second specific aim is to examine the effects of 3-months of treadmill walking exercise training compared with an active control condition on hippocampal volume, hippocampal resting-state functional connectivity, and cardiorespiratory fitness in those persons with MS. We hypothesize that those who are randomly assigned to the treadmill walking exercise condition will demonstrate increases in hippocampal volume and resting-state functional connectivity (i.e., adaptive increases) and improved cardiorespiratory fitness relative to those in the stretching-and-toning condition.
Primary Outcome
Composite z-score of performance on California Verbal Learning Test-II, Selective Reminding Task, Brief Visuospatial Memory Test-Revised, and 10/36 Spatial Recall Test
Interventions
- BEHAVIORAL Treadmill Walking Exercise Training
- BEHAVIORAL Stretching-and-toning Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2018-12-01 |
| Est. Completion | 2021-01-03 |
| Phase | NA |
Why NCT03319771 stopped before completion
NCT03319771 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Treadmill Walking Exercise Training is the first listed.
NCT03319771 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03319771 about?
NCT03319771 is a clinical study titled "Exercise and Learning and Memory in Multiple Sclerosis". The two primary study objectives involve examining the effects of treadmill walking exercise training versus stretching-and-toning activities on the primary and secondary outcomes. Specific Aim 1: The first specific aim is to examine the effects of 3-months of treadmill walking exercise training co...
What is the current status of trial NCT03319771?
This trial is currently terminated. It is a NA study. The enrollment target is 14 participants. The study started on 2018-12-01. Estimated completion is 2021-01-03.
What interventions are being tested in trial NCT03319771?
The interventions under investigation include: Treadmill Walking Exercise Training (BEHAVIORAL), Stretching-and-toning Exercise Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT03319771?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03319771's enrollment target sits among peer trials
14 1909th of 2000 higher than 90 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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