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NCT03305042 · ClinicalTrials.gov registry record
Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death
A clinical trial, sponsored by University of Wisconsin, Madison.
- Completed
- Registry status
- 27
- Enrollment target
NCT03305042: Completed study, sponsored by University of Wisconsin, Madison.
NCT03305042 is a clinical trial that has completed, run by University of Wisconsin, Madison. The registered enrollment target is 27 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03305042 has completed, sponsored by University of Wisconsin, Madison.
- COMPLETED
- Registry status
- 27 participants
- Enrollment target
Study Summary
Minimal human data exist on actual liver vitamin A compared with blood biomarkers. One blood biomarker, the percent of total serum retinol (vitamin A) in the form of retinyl esters, has been suggested to diagnose hypervitaminosis A with cutoffs of 5% and 10%. In this study, investigators aim to compare total liver vitamin A reserves with the percent total serum retinol as retinyl esters to evaluate hypervitaminosis A using autopsy samples from US adults. Investigators also evaluate the sensitivity (the ability of the biomarker to correctly identify those with deficiency) and specificity (the ability of the biomarker to correctly identify those without deficiency) of serum retinol to determine vitamin A deficiency, variation of liver vitamin A concentration among lobes, and liver alpha retinyl ester concentrations, a cleavage product of alpha-carotene, a vitamin A precursor. To conduct the study, matched serum and liver samples were procured from 27 US adult cadavers (from donors age 49-101 years) and their vitamin A biomarkers were analyzed.
Primary Outcome
Concentration of retinyl esters in subjects' serum
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2012-02-01 |
| Est. Completion | 2017-01-31 |
What the finished NCT03305042 record still lists
NCT03305042 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 27 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT03305042 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03305042 about?
NCT03305042 is a clinical study titled "Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death". Minimal human data exist on actual liver vitamin A compared with blood biomarkers. One blood biomarker, the percent of total serum retinol (vitamin A) in the form of retinyl esters, has been suggested to diagnose hypervitaminosis A with cutoffs of 5% and 10%. In this study, investigators aim to comp...
What is the current status of trial NCT03305042?
This trial is currently completed. The enrollment target is 27 participants. The study started on 2012-02-01. Estimated completion is 2017-01-31.
Who is sponsoring clinical trial NCT03305042?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
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