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NCT03303040 · ClinicalTrials.gov registry record · NA
Effect of Diaphragm Stimulation During Surgery
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 25
- Enrollment target
NCT03303040: Completed NA study, sponsored by University of Florida.
NCT03303040 is a NA study that has completed, run by University of Florida. The registered enrollment target is 25 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03303040, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
Study Summary
During major surgical procedures general anesthesia is used to make the patient unconscious. General anesthesia insures that the patient is unaware of any pain caused by surgery. General anesthesia also prevents the patient from moving to prevent any potential surgical error. At the same time general anesthesia makes it impossible for the patient to breathe. To help the patient breathe a breathing tube is placed into the patient's airway and connected to the mechanical ventilator. A mechanical ventilator is an artificial breathing pump, which delivers gas into a patient's airways. The purpose of this research study is to determine if brief periods of diaphragm stimulation can prevent diaphragm problems caused by the use of mechanical ventilators and surgery. To answer this question the changes in the genes responsible for maintaining diaphragm function will be studied. A gene is the code present in each cell in your body and controls the behavior of that cell. In addition, the changes in the contractile properties of muscle fibers will be studied. The results from this study may help develop new treatments to prevent diaphragm weakness resulting from mechanical ventilation use.
Primary Outcome
High-resolution respirometry will be used to assess mitochondrial respiration of permeablilized diaphragm bundles. Addition of substrate medium to the Oroboros O2K respirometry instrument enables quantification of leak respiration and peak uncoupled respiration, expressed as pmol oxygen/sec/mg wet weight.
Interventions
- OTHER Electrical stimulation of hemidiaphragm
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2018-02-14 |
| Est. Completion | 2023-12-31 |
| Phase | NA |
What the finished NCT03303040 record still lists
NCT03303040 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 1 intervention - of which Electrical stimulation of hemidiaphragm is the first listed.
NCT03303040 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03303040 about?
NCT03303040 is a clinical study titled "Effect of Diaphragm Stimulation During Surgery". During major surgical procedures general anesthesia is used to make the patient unconscious. General anesthesia insures that the patient is unaware of any pain caused by surgery. General anesthesia also prevents the patient from moving to prevent any potential surgical error. At the same time genera...
What is the current status of trial NCT03303040?
This trial is currently completed. It is a NA study. The enrollment target is 25 participants. The study started on 2018-02-14. Estimated completion is 2023-12-31.
What interventions are being tested in trial NCT03303040?
The interventions under investigation include: Electrical stimulation of hemidiaphragm (OTHER).
Who is sponsoring clinical trial NCT03303040?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03303040's enrollment target sits among peer trials
25 1712th of 2000 higher than 265 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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