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NCT03301480 · ClinicalTrials.gov registry record
Contraceptive/HIV Affecting Risk in Adolescents
A clinical trial, sponsored by University of Pittsburgh.
- Terminated
- Registry status
- 120
- Enrollment target
NCT03301480: Clinical Trial study, sponsored by University of Pittsburgh.
NCT03301480 is a clinical trial that was terminated before completion, run by University of Pittsburgh. The registered enrollment target is 120 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03301480 was terminated before completion, sponsored by University of Pittsburgh.
- TERMINATED
- Registry status
- 120 participants
- Enrollment target
Study Summary
This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study. HIV risk will be evaluated by the capacity of cervical tissue to replicate HIV when challenged ex vivo and correlated to the number of CD4 T cells, DCs, and macrophages; the capacity of cervicovaginal fluid to inhibit HIV will be correlated to soluble mucosal mediators, and the vaginal microbiota. The lower genital tract samples will be collected from 120 adolescents aged 18-19 (40 using no hormonal contraception, 40 using ENG-I, 40 using LNG-IUS). For comparison, 90 adult women aged 25-45 will be equally distributed between the same groupings.
Primary Outcome
cervical tissue testing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2017-07-31 |
| Est. Completion | 2018-09-17 |
Why NCT03301480 stopped before completion
NCT03301480 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT03301480 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03301480 about?
NCT03301480 is a clinical study titled "Contraceptive/HIV Affecting Risk in Adolescents". This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study. HIV risk will be evaluated by the capacity of cervical tissue to replicate HIV when challenged ex vivo and correlated to t...
What is the current status of trial NCT03301480?
This trial is currently terminated. The enrollment target is 120 participants. The study started on 2017-07-31. Estimated completion is 2018-09-17.
Who is sponsoring clinical trial NCT03301480?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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