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NCT03294694 · ClinicalTrials.gov registry record · Phase 1
Ribociclib + PDR001 in Breast Cancer and Ovarian Cancer
A Phase 1 study, sponsored by Dana-Farber Cancer Institute.
- Terminated
- Registry status
- Phase 1
- Development phase
- 33
- Enrollment target
NCT03294694: Clinical Trial Phase 1 study, sponsored by Dana-Farber Cancer Institute.
NCT03294694 is a Phase 1 study that was terminated before completion, run by Dana-Farber Cancer Institute. The registered enrollment target is 33 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (45% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03294694, a Phase 1 study, was terminated before completion, sponsored by Dana-Farber Cancer Institute.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 33 participants
- Enrollment target
Study Summary
This clinical trial is studying the drug Ribociclib (LEE011) in combination with an immunotherapy drug called PDR001 (a therapy that uses the body's own immune system to control cancer) as a possible treatment for metastatic hormone-receptor-positive (HR+), HER2-negative breast cancer (in combination with fulvestrant) or metastatic epithelial ovarian cancer. The names of the medications involved in this study are: * Ribociclib (LEE011) * PDR001 * Fulvestrant
Primary Outcome
Toxicity will be graded according to NCI CTCAE, Version 4.0.
Interventions
- DRUG Fulvestrant
- DRUG Ribociclib
- DRUG PDR001
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 33 participants |
| Start Date | 2017-11-08 |
| Est. Completion | 2020-10-14 |
| Phase | Phase 1 |
Why NCT03294694 stopped before completion
NCT03294694 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 33 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (45% lower).
The record links to 0 conditions, and to 3 interventions - of which Fulvestrant is the first listed.
NCT03294694 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03294694 about?
NCT03294694 is a clinical study titled "Ribociclib + PDR001 in Breast Cancer and Ovarian Cancer". This clinical trial is studying the drug Ribociclib (LEE011) in combination with an immunotherapy drug called PDR001 (a therapy that uses the body's own immune system to control cancer) as a possible treatment for metastatic hormone-receptor-positive (HR+), HER2-negative breast cancer (in combinatio...
What is the current status of trial NCT03294694?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 33 participants. The study started on 2017-11-08. Estimated completion is 2020-10-14.
What interventions are being tested in trial NCT03294694?
The interventions under investigation include: Fulvestrant (DRUG), Ribociclib (DRUG), PDR001 (DRUG).
Who is sponsoring clinical trial NCT03294694?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03294694's enrollment target sits among peer trials
33 1280th of 2000 higher than 705 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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