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NCT03277638 · ClinicalTrials.gov registry record · Phase 1
Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)
A Phase 1 study of Glioblastoma, Adult, sponsored by Case Comprehensive Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 32
- Enrollment target
- 1
- Study location
NCT03277638 is a Phase 1 study of Glioblastoma, Adult that is active but no longer recruiting, run by Case Comprehensive Cancer Center. The registered enrollment target is 32 participants. The trial reports 1 study location across 1 state.
The verdict
NCT03277638, a Phase 1 study of Glioblastoma, Adult, is active but no longer recruiting, sponsored by Case Comprehensive Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 32 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to test the side effects and efficacy of using Laser Interstitial Thermotherapy (LITT) combined with Pembrolizumab. LITT is a minimally invasive surgical technique that uses a laser to heat brain tumors. Pembrolizumab is an investigational (experimental) drug that works by helping participants' immune system work correctly to detect and fight cancer cells. Pembrolizumab is experimental because it is not approved by the Food and Drug Administration (FDA), for this use, though it is approved to treat other cancers.
Conditions Studied
Interventions
- DRUG Pembrolizumab at 7 days prior
- DRUG Pembrolizumab at 14 days post
- DRUG Pembrolizumab at 35 days post
- PROCEDURE Laser Interstitial Thermotherapy
Study Locations (1)
Ohio
- University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2017-11-29 |
| Est. Completion | 2026-06 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03277638
The ClinicalTrials.gov registry entry for NCT03277638 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Case Comprehensive Cancer Center, which has 407 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Glioblastoma, Adult appearing as the primary indexed condition, and to 4 interventions - of which Pembrolizumab at 7 days prior is the first listed.
NCT03277638 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT03277638 about?
NCT03277638 is a clinical study titled "Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)". The purpose of this study is to test the side effects and efficacy of using Laser Interstitial Thermotherapy (LITT) combined with Pembrolizumab. LITT is a minimally invasive surgical technique that uses a laser to heat brain tumors. Pembrolizumab is an investigational (experimental) drug that works...
What is the current status of trial NCT03277638?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 32 participants. The study started on 2017-11-29. Estimated completion is 2026-06.
What conditions does trial NCT03277638 study?
This clinical trial studies the following conditions: Glioblastoma, Adult.
What interventions are being tested in trial NCT03277638?
The interventions under investigation include: Pembrolizumab at 7 days prior (DRUG), Pembrolizumab at 14 days post (DRUG), Pembrolizumab at 35 days post (DRUG), Laser Interstitial Thermotherapy (PROCEDURE).
Who is sponsoring clinical trial NCT03277638?
This trial is sponsored by Case Comprehensive Cancer Center, which has 407 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03277638 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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