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NCT03273335 · ClinicalTrials.gov registry record
Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 201
- Enrollment target
NCT03273335 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 201 participants.
The verdict
NCT03273335 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 201 participants
- Enrollment target
Study Summary
(From NIH reporter) Each year \>16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory deficits. Although distinct from delirium, POCD (like delirium) is associated with decreased quality of life, long term cognitive decline, early retirement, increased mortality, and a possible increased risk for developing dementia such as Alzheimer's disease. Understanding the etiology of POCD will likely help promote strategies to treat and/or prevent it. A dominant theory holds that brain inflammation causes POCD, but little work has directly tested this theory in humans. The preliminary data of this team strongly suggest that there is significant postoperative neuro-inflammation in older adults who develop POCD. In this K76 award, the investigators will prospectively obtain pre- and post-operative cognitive testing, fMRI imaging and CSF samples in 200 surgical patients over age 65. This will allow the investigators to evaluate the role of specific neuro-inflammatory processes in POCD and its underlying brain connectivity changes.
Interventions
- DEVICE Millipore biomarker assay plate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 201 participants |
| Start Date | 2017-06-15 |
| Est. Completion | 2022-10-21 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03273335
The ClinicalTrials.gov registry entry for NCT03273335 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 201 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Millipore biomarker assay plate is the first listed.
NCT03273335 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03273335 about?
NCT03273335 is a clinical study titled "Investigating NeuroinflammaTion UnderlyIng Postoperative Brain Connectivity Changes, POCD, Delirium in Older Adults". (From NIH reporter) Each year \>16 million older Americans undergo anesthesia and surgery, and up to 40% of these patients develop postoperative cognitive dysfunction (POCD), a syndrome of postoperative thinking and memory deficits. Although distinct from delirium, POCD (like delirium) is associated...
What is the current status of trial NCT03273335?
This trial is currently completed. The enrollment target is 201 participants. The study started on 2017-06-15. Estimated completion is 2022-10-21.
What interventions are being tested in trial NCT03273335?
The interventions under investigation include: Millipore biomarker assay plate (DEVICE).
Who is sponsoring clinical trial NCT03273335?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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