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NCT03271151 · ClinicalTrials.gov registry record · Phase 4
Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty
A Phase 4 study, sponsored by Hospital for Special Surgery, New York.
- Completed
- Registry status
- Phase 4
- Development phase
- 160
- Enrollment target
NCT03271151: Completed Phase 4 study, sponsored by Hospital for Special Surgery, New York.
NCT03271151 is a Phase 4 study that has completed, run by Hospital for Special Surgery, New York. The registered enrollment target is 160 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (69% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03271151, a Phase 4 study, has completed, sponsored by Hospital for Special Surgery, New York.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 160 participants
- Enrollment target
Study Summary
Post-discharge pain after total knee arthroplasty remains problematic; many patients have excessive pain at the 2 week time point (and often thereafter). Reduction in opioid use has become a national goal, due to the 'epidemic' in opioid misuse. In addition to enrolling non-opioid users, we will enroll up to 15 chronic opioid users.
Primary Outcome
Opioid use (measured in cumulative morphine equivalents)
Interventions
- OTHER Placebo
- DRUG Cymbalta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2017-09-28 |
| Est. Completion | 2021-02-19 |
| Phase | Phase 4 |
What the finished NCT03271151 record still lists
NCT03271151 is an interventional study that assigns participants to a tested intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (69% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03271151 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03271151 about?
NCT03271151 is a clinical study titled "Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty". Post-discharge pain after total knee arthroplasty remains problematic; many patients have excessive pain at the 2 week time point (and often thereafter). Reduction in opioid use has become a national goal, due to the 'epidemic' in opioid misuse. In addition to enrolling non-opioid users, we will en...
What is the current status of trial NCT03271151?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 160 participants. The study started on 2017-09-28. Estimated completion is 2021-02-19.
What interventions are being tested in trial NCT03271151?
The interventions under investigation include: Placebo (OTHER), Cymbalta (DRUG).
Who is sponsoring clinical trial NCT03271151?
This trial is sponsored by Hospital for Special Surgery, New York, which has 194 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03271151's enrollment target sits among peer trials
160 507th of 2000 higher than 1,485 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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