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NCT03267940 · ClinicalTrials.gov registry record · Phase 1
Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma
A Phase 1 study, sponsored by Halozyme Therapeutics.
- Terminated
- Registry status
- Phase 1
- Development phase
- 85
- Enrollment target
NCT03267940: Clinical Trial Phase 1 study, sponsored by Halozyme Therapeutics.
NCT03267940 is a Phase 1 study that was terminated before completion, run by Halozyme Therapeutics. The registered enrollment target is 85 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03267940, a Phase 1 study, was terminated before completion, sponsored by Halozyme Therapeutics.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 85 participants
- Enrollment target
Study Summary
The study is being conducted to assess the safety and tolerability of (1) PEGPH20 in combination with CIS and GEM (PEGCISGEM), and (2) PEGPH20 in combination with CIS, GEM, and atezolizumab (PEGCISGEMATEZO) compared with (3) cisplatin and gemcitabine (CISGEM).
Primary Outcome
An AE is any unfavorable or unintended sign, symptom, or disease temporally associated with the use of a pharmaceutical product (for example, study drug), whether or not considered related to the pharmaceutical product. Serious adverse event (SAE) was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapaci
Interventions
- DRUG Atezolizumab
- DRUG PEGPH20
- DRUG CIS
- DRUG GEM
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2017-10-02 |
| Est. Completion | 2019-11-11 |
| Phase | Phase 1 |
Why NCT03267940 stopped before completion
NCT03267940 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (42% higher).
The record links to 0 conditions, and to 4 interventions - of which Atezolizumab is the first listed.
NCT03267940 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03267940 about?
NCT03267940 is a clinical study titled "Study of PEGPH20 With Cisplatin (CIS) and Gemcitabine (GEM); PEGPH20 With Atezolizumab (ATEZO), CIS, and GEM; and CIS and GEM Alone in Participants With Previously Untreated, Unresectable, Locally Advanced, or Metastatic Intrahepatic and Extrahepatic Cholangiocarcinoma and Gallbladder Adenocarcinoma". The study is being conducted to assess the safety and tolerability of (1) PEGPH20 in combination with CIS and GEM (PEGCISGEM), and (2) PEGPH20 in combination with CIS, GEM, and atezolizumab (PEGCISGEMATEZO) compared with (3) cisplatin and gemcitabine (CISGEM).
What is the current status of trial NCT03267940?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 85 participants. The study started on 2017-10-02. Estimated completion is 2019-11-11.
What interventions are being tested in trial NCT03267940?
The interventions under investigation include: Atezolizumab (DRUG), PEGPH20 (DRUG), CIS (DRUG), GEM (DRUG).
Who is sponsoring clinical trial NCT03267940?
This trial is sponsored by Halozyme Therapeutics, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03267940's enrollment target sits among peer trials
85 656th of 2000 higher than 1,342 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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