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NCT03239145 · ClinicalTrials.gov registry record · Phase 1
Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor
A Phase 1 study, sponsored by Dana-Farber Cancer Institute.
- Completed
- Registry status
- Phase 1
- Development phase
- 62
- Enrollment target
NCT03239145: Completed Phase 1 study, sponsored by Dana-Farber Cancer Institute.
NCT03239145 is a Phase 1 study that has completed, run by Dana-Farber Cancer Institute. The registered enrollment target is 62 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03239145, a Phase 1 study, has completed, sponsored by Dana-Farber Cancer Institute.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 62 participants
- Enrollment target
Study Summary
This research study is studying an investigational combination of drugs as a possible treatment for advanced solid tumors: melanoma, ovarian, renal, or colorectal cancer. The drugs involved in this study are: * Pembrolizumab * AMG386
Primary Outcome
A standard 3+3 dose-escalation design was used during dose escalation period. DLT was defined in protocol section 5.5.
Interventions
- DRUG Pembrolizumab
- DRUG Trebananib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2018-05-01 |
| Est. Completion | 2024-12-13 |
| Phase | Phase 1 |
What the finished NCT03239145 record still lists
NCT03239145 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT03239145 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03239145 about?
NCT03239145 is a clinical study titled "Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor". This research study is studying an investigational combination of drugs as a possible treatment for advanced solid tumors: melanoma, ovarian, renal, or colorectal cancer. The drugs involved in this study are: * Pembrolizumab * AMG386
What is the current status of trial NCT03239145?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 62 participants. The study started on 2018-05-01. Estimated completion is 2024-12-13.
What interventions are being tested in trial NCT03239145?
The interventions under investigation include: Pembrolizumab (DRUG), Trebananib (DRUG).
Who is sponsoring clinical trial NCT03239145?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03239145's enrollment target sits among peer trials
62 824th of 2000 higher than 1,173 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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