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NCT03238755 · ClinicalTrials.gov registry record
Mechanisms of Cardiac Dysfunction in HIV and the Effect of Statins: a Cardiac MRI Study
A clinical trial of HIV Infections, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- 129
- Enrollment target
- 4
- Study locations
NCT03238755: Active study of HIV Infections, sponsored by Massachusetts General Hospital.
NCT03238755 is a study of HIV Infections that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 129 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (71% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03238755, a study of HIV Infections, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 129 participants
- Enrollment target
- 4
- Study locations
Study Summary
In this study, investigators plan to test whether statins can preserve and/or improve diastolic function among asymptomatic persons with HIV who are on anti-retroviral therapy. Both myocardial fibrosis and myocardial steatosis are thought to contribute to diastolic dysfunction and eventually overt heart failure in HIV. HIV-positive participants will undergo cardiac MRI/MRS imaging studies for the evaluation of myocardial fibrosis and myocardial steatosis prior to initiation of statin or placebo therapy and then two years after initiation of statin or placebo therapy. Traditional markers of cardiovascular (CVD) risk, systemic immune activation/ inflammation, HIV-specific parameters (i.e. CD4 count), and markers of myocardial stretch/injury will be assessed in relation to cardiac MRI/MRS outcomes.
Conditions Studied
Interventions
- OTHER Cardiac MRI/MRS
Study Locations (4)
California
- VA Medical Center-Los Angeles - Los Angeles
Massachusetts
- Massachusetts General Hospital - Boston
Texas
- UTSW Medical Center - Dallas
Other
- University of Cape Town - Cape Town
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 129 participants |
| Start Date | 2017-07-31 |
| Est. Completion | 2026-04-23 |
What the registry record for NCT03238755 still lists
NCT03238755 is an observational study that tracks outcomes without assigning an intervention. The registered 129 participants enrollment target is mid-sized for trials with a published cap, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (71% lower).
The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 1 intervention - of which Cardiac MRI/MRS is the first listed.
NCT03238755 reports a single indexed study location in California, Massachusetts, Texas.
Frequently Asked Questions
What is clinical trial NCT03238755 about?
NCT03238755 is a clinical study titled "Mechanisms of Cardiac Dysfunction in HIV and the Effect of Statins: a Cardiac MRI Study". In this study, investigators plan to test whether statins can preserve and/or improve diastolic function among asymptomatic persons with HIV who are on anti-retroviral therapy. Both myocardial fibrosis and myocardial steatosis are thought to contribute to diastolic dysfunction and eventually overt h...
What is the current status of trial NCT03238755?
This trial is currently active not recruiting. The enrollment target is 129 participants. The study started on 2017-07-31. Estimated completion is 2026-04-23.
What conditions does trial NCT03238755 study?
This clinical trial studies the following conditions: HIV Infections.
What interventions are being tested in trial NCT03238755?
The interventions under investigation include: Cardiac MRI/MRS (OTHER).
Who is sponsoring clinical trial NCT03238755?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03238755 being conducted?
This trial has 4 study locations across California, Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT03238755's enrollment target sits among peer trials
129 231st of 542 higher than 310 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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