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NCT03233347 · ClinicalTrials.gov registry record · Phase 2
Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma
A Phase 2 study of Classic Hodgkin Lymphoma and Ann Arbor Stage IIB Hodgkin Lymphoma, sponsored by Academic and Community Cancer Research United.
- Active
- Registry status
- Phase 2
- Development phase
- 82
- Enrollment target
- 9
- Study locations
NCT03233347: Active Phase 2 study of Classic Hodgkin Lymphoma and Ann Arbor Stage IIB Hodgkin Lymphoma, sponsored by Academic and Community Cancer Research United.
NCT03233347 is a Phase 2 study of Classic Hodgkin Lymphoma and Ann Arbor Stage IIB Hodgkin Lymphoma that is active but no longer recruiting, run by Academic and Community Cancer Research United. The registered enrollment target is 82 participants, below the 244-participant average among 9 other Classic Hodgkin Lymphoma trials with a reported enrollment target (66% lower). The trial reports 9 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03233347, a Phase 2 study of Classic Hodgkin Lymphoma and Ann Arbor Stage IIB Hodgkin Lymphoma, is active but no longer recruiting, sponsored by Academic and Community Cancer Research United.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 82 participants
- Enrollment target
- 9
- Study locations
Study Summary
This phase II trial evaluates how well AVD (doxorubicin, vinblastine, dacarbazine) in combination with brentuximab vedotin and nivolumab work in treating patients with stage I-II Hodgkin lymphoma. Drugs used in the chemotherapy, such as doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, and/or by stopping them from spreading. Targeted agent, such as nivolumab, may interfere with the ability of cancer cells to grow and spread by enhancing the immune system. Giving doxorubicin, vinblastine, dacarbazine, brentuximab vedotin, and nivolumab may improve survival of patients with stage I-II Hodgkin lymphoma.
Primary Outcome
The distribution of progression-free survival time will be estimated using the method of Kaplan-Meier and the efficacy will be determined by the log rank statistic. Overall progression-free survival at 3 years will be reported.
Conditions Studied
Interventions
- DRUG Doxorubicin
- OTHER Laboratory Biomarker Analysis
- BIOLOGICAL Nivolumab
- DRUG Brentuximab Vedotin
- DRUG Dacarbazine
Study Locations (9)
California
- City of Hope Comprehensive Cancer Center - Duarte
Minnesota
- Mayo Clinic in Rochester - Rochester
Nebraska
- University of Nebraska Medical Center - Omaha
New Jersey
- Hackensack University Medical Center - Hackensack
North Carolina
- Carolinas Medical Center/Levine Cancer Institute - Charlotte
Pennsylvania
- University of Pennsylvania/Abramson Cancer Center - Philadelphia
Tennessee
- Vanderbilt University/Ingram Cancer Center - Nashville
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 82 participants |
| Start Date | 2017-10-13 |
| Est. Completion | 2026-07-08 |
| Phase | Phase 2 |
What the registry record for NCT03233347 still lists
NCT03233347 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 82 participants, a relatively small participant target, below the 244-participant average among 9 other Classic Hodgkin Lymphoma trials with a reported enrollment target (66% lower).
The record links to 7 conditions, with Classic Hodgkin Lymphoma appearing as the primary indexed condition, and to 5 interventions - of which Doxorubicin is the first listed.
NCT03233347 lists 9 locations in 9 states (California, Minnesota, Nebraska).
Frequently Asked Questions
What is clinical trial NCT03233347 about?
NCT03233347 is a clinical study titled "Doxorubicin, Vinblastine, Dacarbazine, Brentuximab Vedotin, and Nivolumab in Treating Patients With Stage I-II Hodgkin Lymphoma". This phase II trial evaluates how well AVD (doxorubicin, vinblastine, dacarbazine) in combination with brentuximab vedotin and nivolumab work in treating patients with stage I-II Hodgkin lymphoma. Drugs used in the chemotherapy, such as doxorubicin, vinblastine, dacarbazine, and brentuximab vedotin,...
What is the current status of trial NCT03233347?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 82 participants. The study started on 2017-10-13. Estimated completion is 2026-07-08.
What conditions does trial NCT03233347 study?
This clinical trial studies the following conditions: Classic Hodgkin Lymphoma, Ann Arbor Stage IIB Hodgkin Lymphoma, Ann Arbor Stage IB Hodgkin Lymphoma, Ann Arbor Stage II Hodgkin Lymphoma, Ann Arbor Stage IIA Hodgkin Lymphoma.
What interventions are being tested in trial NCT03233347?
The interventions under investigation include: Doxorubicin (DRUG), Laboratory Biomarker Analysis (OTHER), Nivolumab (BIOLOGICAL), Brentuximab Vedotin (DRUG), Dacarbazine (DRUG).
Who is sponsoring clinical trial NCT03233347?
This trial is sponsored by Academic and Community Cancer Research United, which has 42 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03233347 being conducted?
This trial has 9 study locations across California, Minnesota, Nebraska, New Jersey, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Classic Hodgkin Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03233347's enrollment target sits among peer trials
82 6th of 9 higher than 4 of 9 other Classic Hodgkin Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Classic Hodgkin Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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